Growing an Embryo from a Single Cell: A Hurdle in Animal Life
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...The existence of a regulative state of pluripotency throughout early development can be considered an innovation of mammalian evolution (Cañon et al., 2011; O’Farrell, 2015)....
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References
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"Growing an Embryo from a Single Cel..." refers background in this paper
...These pluripotency factors are expressed in normal embryonic cells, and sustain pluripotency as the ICM cells of the blastocyst grow and proliferate before gastrulation (Marandel et al. 2012; Le Bin et al. 2014; Sun et al. 2014)....
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"Growing an Embryo from a Single Cel..." refers background in this paper
...The Hira homologs in fish and mouse are similarly required for decompaction (Zhao et al. 2011; Lin et al. 2014)....
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...I suggest that the ability to exchange basic chromatin proteins, whether protamines or histones, with a pool of naı̈ve histones contributes to the ability of the egg to reprogram the epigenetic state of a nucleus (see Lin et al. 2014)....
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"Growing an Embryo from a Single Cel..." refers background in this paper
...Rat embryos show a similarly fast cell-cycle rate of 3–3.5 h near the streak (Mac Auley et al. 1993)....
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132 citations