Growing an Embryo from a Single Cell: A Hurdle in Animal Life
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Cites background from "Growing an Embryo from a Single Cel..."
...The existence of a regulative state of pluripotency throughout early development can be considered an innovation of mammalian evolution (Cañon et al., 2011; O’Farrell, 2015)....
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References
215 citations
"Growing an Embryo from a Single Cel..." refers background in this paper
...The relationship between developmental time and growth is perhaps most obvious in birds, in which the time to hatching in different species increases in proportion to the size of the egg and the hatchling it eventually produces (Rahn et al. 1974)....
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212 citations
"Growing an Embryo from a Single Cel..." refers background in this paper
...These factors appear to act widely to direct transcription of genes necessary to stimulate the developmental potential of the blastomeres of the zebrafish embryo (Lee et al. 2013; Leichsenring et al. 2013)....
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"Growing an Embryo from a Single Cel..." refers background or methods in this paper
...To a large extent, it is the nonyolky cytoplasm that undergoes this phase 2 program to produce an elemental phylotypic embryo, and later the yolk is called on to fund a third phase in the growth and proliferation program, the expansion phase (O’Farrell 2004, 2011; O’Farrell et al. 2004)....
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...In addition to being fast, other similarities that I have previously reviewed suggest parallels between these pregastrulation cell cycles in mammals and the early cleavage cycles (O’Farrell et al. 2004)....
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...If, instead, we align development at the phylotypic stage (O’Farrell et al. 2004), one is struck by the close relationships among the embryos of these model vertebrate organisms, as was von Baer two centuries ago....
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...This insertion obscures relationships even with close vertebrate relatives (O’Farrell et al. 2004)....
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...Understanding the specializations of mammalian development in this context can be illuminating (O’Farrell et al. 2004)....
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