Guidelines for the Management of Rheumatoid Arthritis 2002 Update
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Additional excerpts
...Annual costs rise as the duration of disease increases and as function, measured by the Health Assessment Questionnaire, declines....
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...Functional status may be determined by questionnaires such as the Arthritis Impact Measurement Scales (32) or the Health Assessment Questionnaire (33)....
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...Anakinra also improved the Health Assessment Questionnaire score (154) and reduced radiographic progression (155) compared with placebo....
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3,816 citations
"Guidelines for the Management of Rh..." refers background in this paper
..., as risk reduction for cardiovascular disease), an agent such as low-dose aspirin should be used because, unlike nonselective NSAIDs, the selective COX-2 inhibitors have no effect on platelet adhesion or aggregation (41)....
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...In two recent large trials comparing highly selective COX-2 agents with traditional NSAIDs, the patients in the selective COX-2 agent group had significantly fewer GI events (41,42)....
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...gest that although selective COX-2 inhibitors have a significantly lower risk of serious adverse gastrointestinal (GI) effects than do nonselective NSAIDs (41,42), they are no more effective than nonselective NSAIDs and may cost as much as 15–20 times more per month of treatment than generic NSAIDs....
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...Moreover, the use of a highly selective COX-2 agent has been reported to be associated with a higher rate of thrombotic events (including more myocardial infarctions) compared with traditional NSAIDs (41)....
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3,213 citations
"Guidelines for the Management of Rh..." refers background in this paper
...Nonsteroidal antiinflammatory drugs (NSAIDs), glucocorticoid joint injection, and/or low-dose prednisone may be considered for control of symptoms....
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...Use of NSAIDs and selective COX-2 inhibitors should be avoided in conditions associated with diminished intravascular volume or edema, such as congestive heart failure, nephrotic syndrome, or cirrhosis, and in patients with serum creatinine levels #2.5 mg/dl (50)....
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...addition of low-dose aspirin may partially ameliorate the benefit of less GI toxicity associated with highly selective COX-2 agents (42)....
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...gest that although selective COX-2 inhibitors have a significantly lower risk of serious adverse gastrointestinal (GI) effects than do nonselective NSAIDs (41,42), they are no more effective than nonselective NSAIDs and may cost as much as 15–20 times more per month of treatment than generic NSAIDs....
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...Risk factors for the development of NSAID-associated gastroduodenal ulcers include advanced age, history of ulcer, concomitant use of corticosteroids or anticoagulants, higher dosage of NSAID, use of multiple NSAIDs, or a serious underlying disease (44)....
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2,411 citations
"Guidelines for the Management of Rh..." refers background in this paper
...Both etanercept (94) and infliximab (92,93,95) have been shown to be beneficial when used in combination with MTX in patients with ongoing active RA despite adequate doses of MTX alone....
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