Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition
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"Guidelines for the Management of Se..." refers background in this paper
...6 | VOLUME 80 | NUMBER 1 | JANUARY 2017 www.neurosurgery-online.com D ow nloaded from https://academ ic.oup.com /neurosurgery/article-abstract/80/1/6/2585042 by guest on 17 July 2019 Scope of the Guidelines The guidelines address treatment interventions, monitoring, and treatment thresholds that are specific to TBI or that address a risk that is greater in patients with TBI....
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...Other brain protective mechanisms include inhibition of oxygen radical mediated lipid peroxidation.(2,5,6) Side effects of anesthetics, analgesics, and sedatives include hypotension and decreased cardiac output, as well as increased intrapulmonary shunting, which may lead to hypoxia....
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...Treatment Recommendations Table 1 contains the recommendations for 11 treatments that are either specific to the in-hospital management of severe TBI or are related to risks experienced by patients with TBI....
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...reducing blood viscosity, leading to improved microcirculatory flow of blood constituents and consequent constriction of the pial arterioles, resulting in decreased cerebral blood volume and intracranial pressure.(5,7,8)...
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...Hypertonic saline administration may be hazardous for a hyponatremic patient.(5) Although mannitol can be used as a resuscitation fluid, its eventual diuretic effect is undesirable in hypotensive patients and attention needs to be paid to replacing intravascular volume loss....
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"Guidelines for the Management of Se..." refers background in this paper
...A list of the 41 studies that constitute the new evidence informing these recommendations is cited by topic in Table 4.(4-44) Monitoring Recommendations...
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