Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
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...platelet calcium signaling and elicits a prothrombotic effect in vivo.(10) These observations suggest that TMAO could be a...
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References
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"Gut Microbial Metabolite TMAO Enhan..." refers background in this paper
...The past decade haswitnessed a rapidly growing awareness of the involvement of gut microbial organisms in the development of numerous cardiometabolic phenotypes (Bäckhed et al., 2004; Turnbaugh et al., 2006; Cox et al., 2014)....
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...The past decade haswitnessed a rapidly growing awareness of the involvement of gut microbial organisms in the development of numerous cardiometabolic phenotypes (Bäckhed et al., 2004; Turnbaugh et al., 2006; Cox et al., 2014)....
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5,221 citations
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"Gut Microbial Metabolite TMAO Enhan..." refers background or methods or result in this paper
..., choline, carnitine, gamma butyrobetaine) also accelerates atherosclerosis development, but only in the setting of intact gut microbiota and TMA/TMAO generation (Wang et al., 2011; Koeth et al., 2013, 2014)....
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...Insights into the mechanisms through which the meta-organismal pathway responsible for TMAO production are associated with enhanced CVD risks have thus far focused on the involvement of TMAO and FMO3 in atherosclerotic plaque development, altered sterol and glucose metabolism, and changes in macrophage phenotype (Wang et al., 2011; Koeth et al., 2013; Miao et al., 2015; Shih et al., 2015; Warrier et al., 2015)....
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...In contrast, examination of hepatic FMO enzyme activity, which is responsible for converting TMA into TMAO (Wang et al., 2011; Bennett et al., 2013), revealed no significant differences between both donormouse strains and among the various recipient groups post-cecal microbial transplantation (Figure S6B)....
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...atherosclerotic plaque burden and CVD risks has been observed in multiple distinct clinical studies (Wang et al., 2011; Tang et al., 2013, 2014, 2015; Lever et al., 2014)....
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...…the diet is pro-atherogenic, and similarly, provision of its dietary precursors (e.g., choline, carnitine, gamma butyrobetaine) also accelerates atherosclerosis development, but only in the setting of intact gut microbiota and TMA/TMAO generation (Wang et al., 2011; Koeth et al., 2013, 2014)....
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3,222 citations
"Gut Microbial Metabolite TMAO Enhan..." refers background in this paper
...Insights into the mechanisms through which the meta-organismal pathway responsible for TMAO production are associated with enhanced CVD risks have thus far focused on the involvement of TMAO and FMO3 in atherosclerotic plaque development, altered sterol and glucose metabolism, and changes in macrophage phenotype (Wang et al., 2011; Koeth et al., 2013; Miao et al., 2015; Shih et al., 2015; Warrier et al., 2015)....
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...…affirmed by two distinct studies involving ingestion of either isotope-labeled phosphatidylcholine or isotope-labeled carnitine as a tracer before versus following exposure to an oral cocktail of poorly absorbed antibiotics to suppress intestinal microbes (Tang et al., 2013; Koeth et al., 2013)....
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...…the diet is pro-atherogenic, and similarly, provision of its dietary precursors (e.g., choline, carnitine, gamma butyrobetaine) also accelerates atherosclerosis development, but only in the setting of intact gut microbiota and TMA/TMAO generation (Wang et al., 2011; Koeth et al., 2013, 2014)....
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...…with enhanced CVD risks have thus far focused on the involvement of TMAO and FMO3 in atherosclerotic plaque development, altered sterol and glucose metabolism, and changes in macrophage phenotype (Wang et al., 2011; Koeth et al., 2013; Miao et al., 2015; Shih et al., 2015; Warrier et al., 2015)....
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...Moreover, an obligatory role for gutmicrobes in TMAOgeneration in humans was affirmed by two distinct studies involving ingestion of either isotope-labeled phosphatidylcholine or isotope-labeled carnitine as a tracer before versus following exposure to an oral cocktail of poorly absorbed antibiotics to suppress intestinal microbes (Tang et al., 2013; Koeth et al., 2013)....
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2,188 citations