Gut microbiome composition is linked to whole grain-induced immunological improvements
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1,748 citations
Cites background from "Gut microbiome composition is linke..."
..., 2007), and was associated with improved postprandial glycemic and insulinemic responses (Martı́nez et al., 2013), as well as negatively associated with TIIDM (Qin et al....
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1,503 citations
1,328 citations
Cites background from "Gut microbiome composition is linke..."
...In humans, individuals with higher fecal abundance of the bacterial genus Dialister and lower levels of Coriobacteriaceae family members show reduced serum levels of the pro-inflammatory cytokine IL-6 after short-term consumption of whole grains.(143) In addition to dietary quantity and content, the timing of dietary intake has been recently shown to affect microbiome composition and in turn immunity....
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903 citations
Cites background from "Gut microbiome composition is linke..."
...In addition, intervention studies in humans have demonstrated that dietary fiber and whole grain intake increase gut bacterial diversity.(21,22) Low-fiber intake in Western societies is purported to be a driver in the depletion of the human gastrointestinal microbiota and subsequent increases in chronic non-communicable diseases, such as obesity, cardiovascular disease, type 2 diabetes, and colon cancer....
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806 citations
References
28,911 citations
"Gut microbiome composition is linke..." refers methods in this paper
...Sequence processing was performed combining features of QIIME (Caporaso et al., 2010) and the Ribosomal Database Project pipeline (Cole et al., 2009)....
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...Chao1 species richness estimator, and Shannon’s and Simpson’s (defined as 1-Dominance) diversity indices were computed with QIIME....
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...Sequence processing was performed combining features of QIIME (Caporaso et al., 2010) and the Ribosomal Database Project pipeline (Cole et al....
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16,048 citations
"Gut microbiome composition is linke..." refers methods in this paper
...Sequence processing was performed combining features of QIIME (Caporaso et al., 2010) and the Ribosomal Database Project pipeline (Cole et al., 2009)....
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...Sequences were assigned to a bacterial phylum, family and genus using the Classifier tool of the Ribosomal Database Project (Wang et al., 2007)....
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10,126 citations
"Gut microbiome composition is linke..." refers background in this paper
...Obesity and type 2 diabetes have been linked to alterations in the intestinal microbiota in both the humans and animal models (Ley et al., 2006; Turnbaugh et al., 2006; Cani et al., 2007; Larsen et al., 2010; Vijay-Kumar et al., 2010)....
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7,550 citations
"Gut microbiome composition is linke..." refers background or result in this paper
...If systemic inflammation and cholesterol metabolism impact levels of Ruminococcaceae and Bacteroidetes, respectively, then these interactions could explain the discrepancies related to an altered microbiome in obese versus normoweight individuals (Ley et al., 2006; Duncan et al., 2008; Schwiertz et al., 2010)....
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...…the baseline fecal microbiota of the participants was dominated by the phyla Firmicutes and Bacteroidetes, with lower proportions of Verrucomicrobia and Actinobacteria, in agreement with previous molecular characterizations of the human fecal microbiota (Ley et al., 2006; Martı́nez et al., 2010)....
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...Pyrosequencing revealed that the baseline fecal microbiota of the participants was dominated by the phyla Firmicutes and Bacteroidetes, with lower proportions of Verrucomicrobia and Actinobacteria, in agreement with previous molecular characterizations of the human fecal microbiota (Ley et al., 2006; Martı́nez et al., 2010)....
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...Obesity and type 2 diabetes have been linked to alterations in the intestinal microbiota in both the humans and animal models (Ley et al., 2006; Turnbaugh et al., 2006; Cani et al., 2007; Larsen et al., 2010; Vijay-Kumar et al., 2010)....
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...…inflammation and cholesterol metabolism impact levels of Ruminococcaceae and Bacteroidetes, respectively, then these interactions could explain the discrepancies related to an altered microbiome in obese versus normoweight individuals (Ley et al., 2006; Duncan et al., 2008; Schwiertz et al., 2010)....
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7,536 citations
"Gut microbiome composition is linke..." refers background in this paper
...Furthermore, the gut microbiome might exacerbate the systemic inflammation associated with obesity and related metabolic disorders (Hotamisligil, 2006; Ding et al., 2010), possibly through the induction of endotoxemia driven by lipopolysaccharide translocation through the intestinal epithelium…...
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...Together, these associations substantiate the link between adiposity, a low-grade systemic inflammation, and glucose metabolism (Hotamisligil, 2006)....
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...Most importantly, inflammation has been identified as a main cause of metabolic disorders (Hotamisligil, 2006), and the anti-inflammatory effect could provide a mechanism by which whole grains improve glucose metabolism....
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