Gut microbiome interactions with drug metabolism, efficacy, and toxicity.
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TLDR
The gut microbiota has both direct and indirect effects on drug and xenobiotic metabolisms, and this can have consequences for both efficacy and toxicity in the context of certain types of drug-related toxicity.About:
This article is published in Translational Research.The article was published on 2017-01-01 and is currently open access. It has received 395 citations till now. The article focuses on the topics: Drug metabolism & Gut flora.read more
Citations
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Journal ArticleDOI
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease.
TL;DR: This Review aims to define the key classes of microbial-derived metabolites that are altered in IBD, describe the pathophysiological basis of these associations and identify future targets for precision therapeutic modulation.
Journal ArticleDOI
Microbiota: a key orchestrator of cancer therapy.
Soumen Roy,Giorgio Trinchieri +1 more
TL;DR: The evidence for the ability of the microbiota to modulate chemotherapy, radiotherapy and immunotherapy is discussed with a focus on the microbial species involved, their mechanism of action and the possibility of targeting the microbiome to improve anticancer efficacy while preventing toxicity.
Journal ArticleDOI
Mapping human microbiome drug metabolism by gut bacteria and their genes
Michael B. Zimmermann,Maria Zimmermann-Kogadeeva,Rebekka Wegmann,Rebekka Wegmann,Andrew L. Goodman +4 more
TL;DR: High-throughput genetic analyses and mass spectrometry reveal that the gene products of diverse human gut bacteria affect a wide range of oral drugs, as well as drug metabolism in mice, which has implications for medical therapy and drug development across multiple disease indications.
Journal ArticleDOI
An insight into gut microbiota and its functionalities.
Atanu Adak,Mojibur R. Khan +1 more
TL;DR: An in-depth understanding of the functioning of gut microbiota has led to some very exciting developments in therapeutics, such as prebiotics, probiotics, drugs and faecal transplantation leading to improved health.
Journal ArticleDOI
Non-invasive delivery strategies for biologics.
TL;DR: This Review summarizes the current status, latest updates and future prospects for delivery of peptides, proteins and other biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes.
References
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Journal ArticleDOI
Host-Gut Microbiota Metabolic Interactions
Jeremy K. Nicholson,Elaine Holmes,James Kinross,Rémy Burcelin,Glenn R. Gibson,Wei Jia,Sven Pettersson +6 more
TL;DR: A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Journal ArticleDOI
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
TL;DR: Coloring germ-free mice with Bacteroides thetaiotaomicron reveals that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation.
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Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
Les Dethlefsen,David A. Relman +1 more
TL;DR: The effect of ciprofloxacin on the gut microbiota was profound and rapid, with a loss of diversity and a shift in community composition occurring within 3–4 d of drug initiation and 1 wk after the end of each course, but the return was often incomplete.
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Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
TL;DR: An overview of 'global' mammalian metabolic conversions that should be accounted for in human systems biology models are presented and a new probabilistic approach is proposed to help understand gene–disease relationships and vexed issues of idiosyncratic drug toxicity.
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Long-term impacts of antibiotic exposure on the human intestinal microbiota
Cecilia Jernberg,Sonja Löfmark,Charlotta Edlund,Charlotta Edlund,Janet K. Jansson,Janet K. Jansson +5 more
TL;DR: Evidence that the impacts of some antibiotics remain for extended periods of time in the human microbiome warrant use of prudence in the administration of antibiotics that could aggravate the growing battle with emerging antibiotic-resistant pathogenic strains.
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