Gut Microbiota and Parkinson's Disease: Implications for Faecal Microbiota Transplantation Therapy.
Reads0
Chats0
TLDR
Wang et al. as mentioned in this paper reviewed the latest research to examine the association of gut microbiota with Parkinson's disease and the future prospects of FMT treatment, and suggested the protective and pathogenic effects of certain gut microbial species on PD progression.Abstract:
Parkinson's disease (PD) ranks the second place among neurodegenerative diseases in terms of its morbidity, which affects 1-2% people aged over 65 years. In addition to genetics, some environmental factors may exert vital parts in PD occurrence as well. At present, more and more studies are conducted to elucidate the association between gut microbial dysbiosis and the incidence of PD. Gut microbial dysbiosis has a certain effect on both the central nervous system (CNS) and the enteric nervous system (ENS), which indicates that there is a gut-microbiota-brain axis that induces CNS disorders. Some gut microbial strains are suggested to suppress or weaken the neuroinflammation- and gut-inflammation-immune responses, which suggests the protective and pathogenic effects of certain gut microbial species on PD progression. Therefore, gut microbiome may contain plenty of targets for preventing and managing PD. Faecal microbiota transplantation (FMT) may serve as a direct and useful treatment for PD in the future. Nonetheless, there is little available scientific research in this field. The present work reviewed the latest research to examine the association of gut microbiota with PD, and the future prospects of FMT treatment.read more
Citations
More filters
Journal ArticleDOI
The gut microbiome as a target for adjuvant therapy in insomnia disorder
TL;DR: In this paper , a review aims to summarize the recent literature as an aid to better understand how the alteration of gut microbiota composition contributes to insomnia while evaluating and prospecting the therapeutic effect of modulating gut microbiota in the treatment of insomnia based on previous publications.
Journal ArticleDOI
The gut microbiome as a target for adjuvant therapy in insomnia disorder.
TL;DR: In this paper, a review aims to summarize the recent literature as an aid to better understand how the alteration of gut microbiota composition contributes to insomnia while evaluating and prospecting the therapeutic effect of modulating gut microbiota in the treatment of insomnia based on previous publications.
Posted ContentDOI
NEMoE: A nutrition aware regularized mixture of experts model addressing diet-cohort heterogeneity of gut microbiota in Parkinson’s disease
Xiangnan Xu,Michal Lubomski,Michal Lubomski,Michal Lubomski,Andrew J. Holmes,Carolyn M. Sue,Carolyn M. Sue,Ryan L. Davis,Samuel Müller,Samuel Müller,Jean Yee Hwa Yang +10 more
TL;DR: In this paper, a regularized mixture of experts model framework was proposed to identify diet-specific microbiome markers of disease in a Parkinson9s disease cohort using a series of simulation studies.
Journal ArticleDOI
Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance
TL;DR: The role of the Gut microbiota in the GBA has been documented for different regulatory mechanisms and associated pathways and it shows different behaviors with individualized bacteria as mentioned in this paper , implying that it performs a significant role in neurocrine, endocrine, and immune-mediated signaling pathways.
Journal ArticleDOI
The fecal arsenic excretion, tissue arsenic accumulation, and metabolomics analysis in sub-chronic arsenic-exposed mice after in situ arsenic-induced fecal microbiota transplantation.
Yu Luo,Jiating Wang,Chenfei Wang,Dongbin Wang,Chengjian Li,Bin Zhang,Xiaoting Zhong,Linkang Chen,Hao Li,Hongtian Su,Qiuyi Zheng,Dajian Zhu,Huanwen Tang,Lian-Xian Guo +13 more
TL;DR: Zhang et al. as discussed by the authors explored the potential of microbial detoxification via gut microbiome in the treatment of sub-chronic arsenic poisoning by exposing mice to high-dose arsenic feed (30 mg/kg, rice arsenic composition) for 60 days.
References
More filters
Journal ArticleDOI
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Journal ArticleDOI
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more
TL;DR: It is reported herein that gut microbiota are required for motor deficits, microglia activation, and αSyn pathology, and suggested that alterations in the human microbiome represent a risk factor for PD.
Journal ArticleDOI
Gut-brain axis: how the microbiome influences anxiety and depression
TL;DR: Recent findings showing that microbiota are important in normal healthy brain function are reviewed, and ongoing and future animal and clinical studies aimed at understanding the microbiota-gut-brain axis may provide novel approaches for prevention and treatment of mental illness.
Journal ArticleDOI
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Gerard Clarke,Sue Grenham,Paul Scully,Patrick Fitzgerald,Rachel D. Moloney,Fergus Shanahan,Timothy G. Dinan,John F. Cryan +7 more
TL;DR: It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life.
Related Papers (5)
Dysbiosis of gut microbiota and microbial metabolites in Parkinson's Disease.
Meng-Fei Sun,Yan-Qin Shen +1 more