Journal ArticleDOI
Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.
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TLDR
The role of the gut microbiota and metabolic endotoxemia-induced inflammation in the development of obesity and liver injury is reviewed, with special reference to the intensive care unit setting.Abstract:
Obesity and its metabolic complications are major health problems in the United States and worldwide, and increasing evidence implicates the microbiota in these important health issues. Indeed, it appears that the microbiota function much like a metabolic “organ,” influencing nutrient acquisition, energy homeostasis, and, ultimately, the control of body weight. Moreover, alterations in gut microbiota, increased intestinal permeability, and metabolic endotoxemia likely play a role in the development of a chronic low-grade inflammatory state in the host that contributes to the development of obesity and associated chronic metabolic diseases such as nonalcoholic fatty liver disease. Supporting these concepts are the observations that increased gut permeability, low-grade endotoxemia, and fatty liver are observed in animal models of obesity caused by either high-fat or high-fructose feeding. Consistent with these observations, germ-free mice are protected from obesity and many forms of liver injury. Last, man...read more
Citations
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Journal ArticleDOI
The Impact of Diet and Lifestyle on Gut Microbiota and Human Health
TL;DR: A narrative review explores the relevant contemporary scientific literature to provide a general perspective of the role of diet and other environmental factors in modulating the composition and metabolic activity of the human gut microbiota, which in turn can impact health.
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Gut/brain axis and the microbiota
TL;DR: Evidence suggests that multiple mechanisms, including endocrine and neurocrine pathways, may be involved in gut microbiota-to-brain signaling and that the brain can in turn alter microbial composition and behavior via the autonomic nervous system.
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Gut microbiota in health and disease
TL;DR: The present article deals with the nomenclature, modern study techniques, and functions of gut microbiota, and its relation to health and disease.
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Sterile Inflammation in the Liver
Paul Kubes,Wajahat Z. Mehal +1 more
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The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids
Jingyuan Fu,Marc Jan Bonder,María Carmen Cenit,Ettje F. Tigchelaar,Astrid Maatman,Jackie A M Dekens,Eelke Brandsma,Joanna Marczynska,Floris Imhann,Rinse K. Weersma,Lude Franke,Tiffany W. Poon,Ramnik J. Xavier,Dirk Gevers,Marten H. Hofker,Cisca Wijmenga,Alexandra Zhernakova +16 more
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References
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Journal ArticleDOI
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Journal ArticleDOI
Obesity alters gut microbial ecology
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