H2S Signals Through Protein S-Sulfhydration
Citations
1,560 citations
Cites background or methods from "H2S Signals Through Protein S-Sulfh..."
...1 subunits heterologously expressed in HEK293 cells has also been reported based on the biotin switch assay result (420)....
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...DTT treatment also released more H2S from Na2S preabsorbed brain homogenates than without preabsorption....
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...In contrast, Snitrosylation may only be applicable to 1–2% of targeted proteins (420)....
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...This is evidenced by the 25–30% reduction of liver GAPDH sulfhydration after CSE is knocked out and endogenous H2S production is minimized despite normal levels of GAPDH protein (420)....
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...Cys150 of GAPDH can be nitrosylated (230) or sulfhydrated (420), for example....
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1,129 citations
Cites background from "H2S Signals Through Protein S-Sulfh..."
...HYDROGEN SULFIDE IN CELL SIGNALING—THE ROLE OF S-SULFHYDRATION H2S causes S-sulfhydration of a large number of cellular proteins (71); this process is potentially significant because it provides a possible mechanism by which H2S alters the function of a wide range of cellular proteins and enzymes....
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...Recently, the KATP channel has been reported to be sulfhydrated by H2S (71)....
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...S-sulfhydration seems to be a common posttranslational modification event in the cell, with 10–25% of all mouse liver proteins reported to exist in this state (71)....
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References
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"H2S Signals Through Protein S-Sulfh..." refers background in this paper
...derived relaxing factor activity of H2S involves opening of adenosine 5′-triphosphate (ATP)–sensitive potassium channels (6, 14)....
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1,639 citations
"H2S Signals Through Protein S-Sulfh..." refers background in this paper
...Recent evidence indicates that hydrogen sulfide (H2S) also acts as a messenger to elicit hibernation states (2), inhibit insulin signaling (3), and regulate inflammation (4) and blood vessel caliber (5)....
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...We elected to study sulfhydration in the liver because it generates high amounts of H2S (4)....
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1,386 citations