H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
Heather Francis,Antonio Franchitto,Yoshiyuki Ueno,Shannon Glaser,Sharon DeMorrow,Julie Venter,Eugenio Gaudio,Domenico Alvaro,Giammarco Fava,Marco Marzioni,Bradley Vaculin,Gianfranco Alpini +11 more
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TLDR
Downregulation of cAMP-dependent PKA/ERK1/2/Elk-1 phosphorylation (by activation of H3R) is important in the inhibition of cholangiocyte growth in liver diseases.About:
This article is published in Laboratory Investigation.The article was published on 2007-05-05 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Cholangiocyte proliferation & Thioperamide.read more
Citations
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Journal ArticleDOI
Histamine H3 Receptor Antagonists Go to Clinics
TL;DR: First data published on clinical trials phase II (IIb) are presented showing proof of concept of H(3) receptor antagonists in narcolepsy and photo-induced epilepsy.
Journal ArticleDOI
Cholangiocyte proliferation and liver fibrosis.
TL;DR: The role of proliferating cholangiocytes in the induction of fibrosis either directly via epithelial mesenchymal transition or indirectly via the activation of other liver cell types is discussed.
Journal ArticleDOI
Epigenetic regulation of miR-34a expression in alcoholic liver injury
Fanyin Meng,Shannon Glaser,Shannon Glaser,Heather Francis,Heather Francis,Fuquan Yang,Yuyan Han,Allison Stokes,Dustin Staloch,Jennifer McCarra,Jingang Liu,Julie Venter,Haiying Zhao,Xiuping Liu,Taylor Francis,Scott Swendsen,Chang-Gong Liu,Hidekazu Tsukamoto,Hidekazu Tsukamoto,Gianfranco Alpini,Gianfranco Alpini +20 more
TL;DR: Modulation of miR-34a altered expression of matrix metalloproteases 1 and 2, the mediators involved in hepatic remodeling during alcoholic liver fibrosis, and revealed that caspase-2 and sirtuin 1 are the direct targets of MiRNAs.
Journal ArticleDOI
Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway
Heather Francis,Shannon Glaser,Sharon DeMorrow,Eugenio Gaudio,Yoshiyuki Ueno,Julie Venter,David E. Dostal,Paolo Onori,Antonio Franchitto,Marco Marzioni,Shelley Vaculin,Bradley Vaculin,Khurshed A. Katki,Monique Stutes,Jennifer Savage,Gianfranco Alpini +15 more
TL;DR: In this article, small and large cholangiocytes were treated with histamine trifluoromethyl toluidide (HTMT dimaleate; HRH1 agonist) for 24-48 h with/without terfenadine, BAPTA/AM, or W7 before measuring proliferation.
Journal ArticleDOI
Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis.
TL;DR: The role of Histamine in pathogenesis of MS is clarified as well as the efficacy of histamine receptors agonists and antagonists in treatment of this disease is evaluated.
References
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Book
The Liver: Biology and pathobiology
TL;DR: The role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function and the Regeneration of Hepatocyte Growth and Pathobiology are discussed.
Journal ArticleDOI
The Liver: Biology and Pathobiology
TL;DR: This book is not, however, another catechism of clinical liver disease, but an effort to encapsulate knowledge in the expanding field of hepatobiology, and produces a definitive text on the biology and pathobiology of the liver.
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Histaminergic transmission in the mammalian brain
TL;DR: Article de synthese sur le metabolisme de l'histamine, sur la localisation des voies neuronales and des recepteurs histaminergiques, dans le controle neuroendocrine dans la regulation cardiovasculaire.
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HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY
Alexander M. Rutenburg,Hwakyu Kim,Jerome W. Fischbein,Jacob S. Hanker,Hannah L. Wasserkrug,Arnold M. Seligman +5 more
TL;DR: In this paper, a simultaneous coupling azo dye method for the histochemical demonstration of γ-glutamyl transpeptidase activity using the new substrate γglutamide-4methoxy-2-naphthylamide has been described.
Journal ArticleDOI
Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation.
TL;DR: This review examines the cell type-specific effects of cAMP on the mitogen-activated protein (MAP) kinase (also called extracellular signal-regulated kinase, or ERK) cascade and cell proliferation and suggests that one of these mechanisms might involve the activation of the GTPase Rap1, which can activate or inhibit ERK signaling in a cell-specific manner.
Related Papers (5)
Vascular Endothelial Growth Factor Stimulates Rat Cholangiocyte Proliferation Via an Autocrine Mechanism
Eugenio Gaudio,Barbara Barbaro,Barbara Barbaro,Domenico Alvaro,Shannon Glaser,Heather Francis,Yoshiyuki Ueno,Cynthia J. Meininger,Antonio Franchitto,Paolo Onori,Marco Marzioni,Silvia Taffetani,Giammarco Fava,George Stoica,Julie Venter,Ramona Reichenbach,Sharon De Morrow,Ryun Summers,Gianfranco Alpini +18 more