Hematopoietic reconstitution in a patient with fanconi's anemia by means of umbilical-cord blood from an hla-identical sibling
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"Hematopoietic reconstitution in a p..." refers background or methods or result in this paper
...* The preparation for the assays has been described elsewhere [12]....
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...This use of cord blood followed the suggestion of one of us that blood retrieved from umbilical cord at delivery, usually discarded, might restore hematopoiesis – a proposal supported by preparatory studies by some of us [12] and consistent with reports on the presence of hematopoietic stem and multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells in human umbilical-cord blood (see the references cited by Broxmeyer et al. [12])....
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...Immediately after the birth of the patient‘s sister, blood was obtained from her umbilical cord and the placenta as described elsewhere [12] and transported at ambient temperature by overnight express service to a laboratory for cellular analysis, cryopreservation, and storage (Indiana University School of Medicine)....
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...Bone marrow and, under certain circumstances, the blood of adults (see references cited by Broxmeyer et al [12]) and the liver of fe- tuses [17] have been used in the transplantation of hematopoietic cells....
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...These values were within the range associated with successful transplantation of HLA–matched allogeneic bone marrow [12]....
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"Hematopoietic reconstitution in a p..." refers background or methods in this paper
...Hypersensitivity to the clastogenic effect of DNA-cross-linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of Fanconi’s anemia, both prenatally and postnatally [3-6]....
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...Chromosome-breakage studies were performed as described elsewhere [4]....
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