Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia.
Silvana Fahel da Fonseca,Tatiana Amorim,Antônio Purificação,Marilda Souza Goncalves,Ney Boa-Sorte +4 more
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Hb A2 levels are elevated in patients with Hb S or Hb C, and are directly influenced by the alpha thalassemia genotypes.Abstract:
a b s t r a c t Background: In sickle cell disease, the quantification of Hb A2 is important for the differentialread more
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Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins
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TL;DR: This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles) and a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein.
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Techniques for the Detection of Sickle Cell Disease: A Review.
TL;DR: An overview of the current and emerging techniques for sickle cell disease detection and highlights the different potential methods that could be applied to help the early diagnosis of SCD can be found in this paper.
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Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Amani M. Al-Amodi,Neda Z. Ghanem,Sumayh A Aldakeel,Lubna Ibrahim Al Asoom,Nazish Rafique Ahmed,Noor B. Almandil,Zaki A. Naserullah,Sana Al-Jarrash,Mohammed Shakil Akhtar,Sayed AbdulAzeez,Amein K. Al-Ali,J. Francis Borgio +11 more
TL;DR: HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers, and can be incorrectly diagnosed as carriers.
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Knowledge of professional healthcare providers about sickle cell disease: Impact of a distance education course
Katy Karoline Santos Diniz,Adriana Silvina Pagano,Ana Paula Fernandes,Ilka Afonso Reis,Leonardo Gonçalves Pinheiro Júnior,Heloisa de Carvalho Torres +5 more
TL;DR: Participation in a distance education course on sickle cell disease had a positive impact on the acquisition of knowledge about the disease by professional healthcare providers.
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The importance of hemoglobin A2 determination.
TL;DR: Level was influenced by the genotype of -Thal, and the diagnosis of doubleheterozygous states, such as S- Thal, should be carried out care-fully, taking into consideration the limitations of the available laboratory techniques.
References
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Journal ArticleDOI
Prevalence and molecular characterization of β-thalassemia in the state of Bahia, Brazil: first identification of mutation HBB: c.135delC in Brazil.
TL;DR: This is the first study to determine the prevalence and profile of β-thal in Bahia State and report the occurrence of the HBB: c.135delC mutation in the β-globin gene for the first time in Brazil.
Journal Article
HPLC determination of hemoglobins to establish reference values with the aid of statistics and informatics.
L S Ondei,Paula J. A. Zamaro,P. H. Mangonaro,Carlos Roberto Valêncio,Claudia Regina Bonini-Domingos +4 more
TL;DR: The Hb values established will be available for use as a reference for the Brazilian population, drawing attention to the increased levels of Hb A2, which should be considered with caution to prevent incorrect diagnoses.
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Breastfeeding and the anthropometric profile of children with sickle cell anemia receiving follow-up in a newborn screening reference service
Zeni Drubi Nogueira,Ney Boa-Sorte,Maria Efigênia Q. Leite,Márcia Miyuki Kiya,Tatiana Amorim,Silvana Fahel da Fonseca +5 more
TL;DR: EBF time and weaning age were greater than that found in the literature, which is a possible effect of the multidisciplinary follow-up and duration of EBF and later weaning were associated with improved anthropometric indicators.
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Aleitamento materno e perfil antropométrico de criancas com doenca falciforme acompanhadas em servico de referência em triagem neonatal
Zeni Drubi Nogueira,Ney Boa-Sorte,Maria Efigênia Q. Leite,Márcia Miyuki Kiya,Tatiana Amorim,Silvana Fahel da Fonseca +5 more
TL;DR: In this paper, a study of 357 criancas with doenca falciforme (DF) and hemoglobinopatia SS (SS) was carried out in Triagem Neonatal (SRTN).