Hemostatic defects in dysproteinemias.
TL;DR: The mechanism of defective hemostasis is uncertain, and a bewildering inconsistency of abnormal findings, some of which appear to correlate with bleeding while others do not, is described.
About: This article is published in Blood.The article was published on 1970-05-01 and is currently open access. It has received 136 citations till now. The article focuses on the topics: Abnormal bleeding & Paraproteins.
Citations
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TL;DR: Eight patients with pleural effusion caused by myeloma are added to the eight cases reported in the literature, and thoracic skeletal or pleuropulmonary abnormalities or both are disclosed in 443 patients.
Abstract: Review of the records of 958 patients with multiple myeloma disclosed thoracic skeletal or pleuropulmonary abnormalities or both in 443 patients (46%). The abnormalities were an initial finding on 25% of the chest roentgenograms. The most common finding, exclusive of plasmacytomas, was thoracic skeletal abnormality in 28% (the initial finding in 15%)—osteolytic lesions being the most frequent abnormality. Localized or diffuse pulmonary infiltrates, most often caused by infections, were present in 10%. Four patients had a diffuse infiltrate thought to be caused by a plasma cell infiltrate (proven in one). In 113 patients, plasmacytomas were seen (intramedullary 102, extramedullary 11)—as an initial finding in 8%. Fifty-eight patients (6%) had pleural effusions. Eight patients with pleural effusion caused by myeloma are added to the eight cases reported in the literature. ( Arch Intern Med 138:727-730, 1978)
197 citations
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TL;DR: Modified Ivy bleeding time (template) and platelet aggregation to ADP, epinephrine, and collagen were studied in 26 uremic patients who had not recently ingested anti‐platelet drugs, and aggregometric patterns differed between drug‐induced and Uremic thrombocytopathies.
Abstract: Modified Ivy bleeding time (template) and platelet aggregation to ADP, epinephrine, and collagen were studied in 26 uremic patients who had not recently ingested anti-platelet drugs. Regardless of the aggregating agent used, the abnormalities in platelet aggregation were often mild, even with advanced uremia, and frequently less severe than the effects of common anti-platelet drugs. The inhibition of collagen-induced aggregation was significantly correlated with both increased bleeding time and blood urea nitrogen. Platelet aggregation was not discriminative between clinically bleeding and non-bleeding groups of patients, but the bleeding time was helpful in this regard. In certain cases, the aggregometric patterns differed between drug-induced and uremic thrombocytopathies. Platelet aggregometry appears to be of little help clinically in assessing the severity of the uremic bleeding diathesis.
182 citations
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TL;DR: It was found that attempts to classify patients with Waldenstrom’s macroglobulinemia as primary or secondary frequently proved in error with long-term observation and as such should be discarded.
164 citations
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TL;DR: The coagulation laboratory findings in patients with acquired von Willebrand disease and the thromboembolic and hemorrhagic manifestations of malignancy are reviewed.
Abstract: Coagulation disorders are common in cancer patients. This article reviews the coagulation laboratory findings in these patients and the thromboembolic and hemorrhagic manifestations of malignancy. Among the many topics addressed are Trousseau's syndrome, disseminated intravascular coagulation, and acquired von Willebrand disease. Pathogenesis of the coagulation disorders and recommendations for treatment of various syndromes are discussed.
124 citations
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TL;DR: A United Kingdom Haemophilia Centre Doctors’ Organization (UKHCDO) guideline approved by the British Committee for Standards in Haematology.
Abstract: A United Kingdom Haemophilia Centre Doctors’ Organization (UKHCDO) guideline approved by the British Committee for Standards in Haematology Peter W Collins, Elizabeth Chalmers, Daniel Hart, Ian Jennings, Ri Liesner, Savita Rangarajan, Kate Talks, Michael Williams and Charles R. M. Hay School of Medicine, Cardiff University, University Hospital of Wales, Cardiff, Royal Hospital for Sick Children, Glasgow, Royal London Hospital, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK NEQAS Blood Coagulation, Sheffield, Great Ormond Street NHS Trust, London, Hampshire Hospital NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Basingstoke, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle, Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, and Manchester University Dept of Haematology, Manchester Royal Infirmary, Manchester, UK
112 citations
Cites background from "Hemostatic defects in dysproteinemi..."
...Other acquired inhibitors directed against human thrombin are usually associated with autoimmune conditions, monoclonal gammopathies or a polyclonal increase in immunoglobulin (Craddock et al, 1953; Frick, 1955; Perkins et al, 1970; Gabriel et al, 1987)....
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References
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TL;DR: In vitro measurements of platelet adhesiveness are consistent with the thesis that the initial aggregation of platelets in hemostasis is not dependent on blood coagulation.
468 citations
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TL;DR: This work has devised a modification of the Biggs and Douglas test, which it is felt allows a higher degree of accuracy, as well as solving the problem and eliminating the need for siliconized glassware.
Abstract: THE test described in 1953 by Biggs and Douglas1 has proved a valuable technique for the study of the generation of plasma thromboplastin, and in the diagnosis of the various haemorrhagic states due to defects at this level. Of the three ingredients for the ‘incubation mixture’, as originally described, only the preparation of a consistently satisfactory platelet suspension is troublesome and time-consuming enough to cause difficulties for those not constantly using the test. We have devised a modification, which we feel allows a higher degree of accuracy, as well as solving this problem and eliminating the need for siliconized glassware.
454 citations
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197 citations
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TL;DR: A passive hemagglutination technique employing isolated γ-globulins and myeloma proteins of known genetic types coated onto human group O cells by CrCl3 method has been developed and cells thus coated have been successfully used for Gm and Inv typing of human sera.
Abstract: A passive hemagglutination technique employing isolated γ-globulins and myeloma proteins of known genetic types coated onto human group O cells by CrCl3 method has been developed. Cells thus coated have been successfully used for Gm and Inv typing of human sera. The degree of discrimination between inhibiting and noninhibiting sera is as great as with the conventional method using cells coated with incomplete anti-Rh.
161 citations
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TL;DR: A marked increase in serum viscosity may be responsible for many of the disease manifestations of pathologic states associated with elevated serum macroglobulin levels.
Abstract: Excerpt A marked increase in serum viscosity may be responsible for many of the disease manifestations of pathologic states associated with elevated serum macroglobulin levels. For this reason, rat...
131 citations