Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu.
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TLDR
The present review aims at summarizing the current knowledge in liver ischemia-reperfusion, but specifically focusing on liver cell phenotype and paracrine interaction deregulations, as well as some of the scientific controversies in the field.About:
This article is published in Journal of Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 428 citations till now. The article focuses on the topics: Liver cell & Liver transplantation.read more
Citations
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Liver sinusoidal endothelial cells: Physiology and role in liver diseases.
Johanne Poisson,Sara Lemoinne,Chantal M. Boulanger,Chantal M. Boulanger,François Durand,Richard Moreau,Richard Moreau,Dominique Valla,Dominique Valla,Pierre-Emmanuel Rautou +9 more
TL;DR: This review provides an overview of the strategies available for a specific targeting of LSECs and presents a detailed analysis of the technical aspects relevant for LSEC analysis including the markers these cells express, the available cell lines and the transgenic mouse models.
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Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress
Samer Tohme,Hamza O. Yazdani,Ahmed B. Al-Khafaji,Alexis P. Chidi,Patricia Loughran,Kerri A. Mowen,Yanming Wang,Richard L. Simmons,Hai Huang,Allan Tsung +9 more
TL;DR: These findings implicate NET in the development of liver metastases after surgical stress, suggesting that their elimination may reduce risks of tumor relapse.
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Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
TL;DR: The role of LSECs in initiating immune responses and contributing to progressive liver disease makes them a potential therapeutic target for treating inflammatory liver diseases.
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Challenges to Liver Transplantation and Strategies to Improve Outcomes
Philipp Dutkowski,Michael Linecker,Michelle L. DeOliveira,Beat Müllhaupt,Pierre-Alain Clavien +4 more
TL;DR: Significant changes in indications for LT are focused on and scoring systems to best match donors with recipients and optimize outcomes are discussed, particularly for the sickest patients.
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Liver Macrophages: Old Dogmas and New Insights.
TL;DR: Liver macrophages have been thoroughly studied in human disease and mouse models, unravelling that the hepatic mononuclear phagocyte system is more versatile and complex than previously believed.
References
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Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.
TL;DR: On the basis of current knowledge, preconditioning or pharmacological interventions that mimic these effects have the greatest potential to improve clinical outcome in liver surgery involving ischemic stress and reperfusion.
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Platelet-Derived Serotonin Mediates Liver Regeneration
Mickael Lesurtel,Rolf Graf,Boris Aleil,Diego J. Walther,Yinghua Tian,Wolfram Jochum,Christian Gachet,Michael Bader,Pierre-Alain Clavien +8 more
TL;DR: Results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration and blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin.
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The utility of marginal donors in liver transplantation.
Ronald W. Busuttil,Koichi Tanaka +1 more
TL;DR: The utility of various marginal donors in patients requiring liver transplantation will be described, including older donors, steatotic livers, non‐heart‐beating donors, donors with viral hepatitis, and donors with malignancies.
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Hepatic ischemia-reperfusion injury.
TL;DR: Application of the knowledge gained from animal models of hepatic ischemia-reperfusion to the clinical setting will improve the outcome of hepatics surgery.
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Protective strategies against ischemic injury of the liver.
TL;DR: Strategies to protect the liver from injuries caused by ischemia and reperfusion and gene therapy to enhance the survival and viability of the liver in various surgical procedures including liver transplantation are summarized.