Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Rohit Loomba,T. Jake Liang +1 more
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TLDR
This review provides a comprehensive update on the current concepts, risk factors, molecular mechanisms, prevention, and management of hepatitis B reactivation and provides recommendations for future research in this area.About:
This article is published in Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 399 citations till now. The article focuses on the topics: Hepatitis B virus & HBsAg.read more
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Hepatitis B virus infection
Man-Fung Yuen,Ding-Shinn Chen,Ding-Shinn Chen,Geoffrey Dusheiko,Harry L.A. Janssen,Daryl T.-Y. Lau,Stephen Locarnini,Marion G. Peters,Ching-Lung Lai +8 more
TL;DR: This Primer addresses several aspects of HBV infection, including epidemiology, immune pathophysiology, diagnosis, prevention and management, including antiviral agents that directly act on viral replication and immunomodulators, such as interferon therapy.
Journal ArticleDOI
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases.
Cara L. Mack,David H. Adams,David N. Assis,Nanda Kerkar,Michael P. Manns,M.J. Mayo,John M. Vierling,Mouaz Alsawas,Mohammad Hassan Murad,Albert J. Czaja +9 more
TL;DR: This practice guideline/guidance constitutes an update of the guidelines on AIH published in 2010 by the American Association for the Study of Liver Diseases (AASLD) and updates the epidemiology, diagnosis, management, and outcomes of AIH in adults and children.
Journal ArticleDOI
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
Giovanni Raimondo,Stephen Locarnini,Teresa Pollicino,Massimo Levrero,Fabien Zoulim,Anna S. Lok,Jean-Pierre Allain,Thomas Berg,Antonio Bertoletti,Maurizia Rossana Brunetto,Raffaele Bruno,Ding-Shinn Chen,Nicola Coppola,Markus Cornberg,Antonio Craxì,Maura Dandri,Vito Di Marco,C. Ferrari,Giovanni Battista Gaeta,Dieter Glebe,Luca G. Guidotti,Anna Kramvis,Pietro Lampertico,Chengyao Li,Jake Liang,Alfredo Marzano,Thomas I. Michalak,Jean-Michel Pawlotsky,Daniele Prati,Massimo Puoti,Didier Samuel,Vincent Soriano,Giovanni Squadrito,Camille Sureau,Christian Trepo,Man-Fung Yuen +35 more
TL;DR: The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both the existing controversial and newly emerging aspects, and ultimately to update the statements previously agreed in 2008.
Journal ArticleDOI
Hepatitis B Virus: Advances in Prevention, Diagnosis, and Therapy.
TL;DR: A global approach is taken by using the findings of global experts on HBV as well as citing major guidelines and their various approaches to addressing HBV and its disease burden to provide a more relevant document to regions worldwide.
Journal ArticleDOI
Circulating and intrahepatic antiviral B cells are defective in hepatitis B
Alice R Burton,Laura J. Pallett,Laura E. McCoy,Kornelija Suveizdyte,Oliver E. Amin,Leo Swadling,Elena Alberts,Brian R. Davidson,Patrick T F Kennedy,Upkar S. Gill,Claudia Mauri,Paul A. Blair,Nadege Pelletier,Mala K. Maini +13 more
TL;DR: It was found that HBsAg-specific B cells persisted in the blood and liver of many patients with CHB and were enriched for T-bet, a signature of antiviral potential in B cells, however, purified, differentiated HBs Ag- specific B cells from patients withCHB had defective antibody production, consistent with undetectable anti-HBs antibodies in vivo.
References
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TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
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Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
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Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Shiv Kumar Sarin,Manoj Kumar,George K. K. Lau,Zaigham Abbas,Henry Lik-Yuen Chan,Chien-Jen Chen,Ding-Shinn Chen,Huey-Ling Chen,Pei-Jer Chen,Rong-Nan Chien,Abdul Kadir Dokmeci,Edward Gane,J L Hou,Wasim Jafri,Jidong Jia,J. H. Kim,Ching-Lung Lai,Hon Cheung Lee,Seng Gee Lim,Chun-Jen Liu,Stephen Locarnini,M. Al Mahtab,Rosmawati Mohamed,Masao Omata,Jun Yong Park,Teerha Piratvisuth,Barjesh Chander Sharma,Jose D. Sollano,Fu-Sheng Wang,Lai Wei,Man-Fung Yuen,Shusen Zheng,Jia-Horng Kao +32 more
TL;DR: The final clinical practice guidelines and recommendations for the optimal management of chronic HBV infection are presented here, along with the relevant background information.
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Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Huan Yan,Guocai Zhong,Guangwei Xu,Wenhui He,Zhiyi Jing,Zhenchao Gao,Yi Huang,Yonghe Qi,Bo Peng,Haimin Wang,Liran Fu,Mei Song,Pan Chen,Wenqing Gao,Bijie Ren,Yinyan Sun,Tao Cai,Xiaofeng Feng,Jianhua Sui,Wenhui Li +19 more
TL;DR: It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
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Chronic hepatitis B : an update
Naoky C. S. Tsai,Norman Gitlin +1 more
TL;DR: A group of experts in this field is assembled to present their expertise in such a level, where the practicing clinicians who deal with this disease in their daily practice can understand thereby implement this knowledge into their own practice.
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