Hepatitis B virus infection [1] (multiple letters)
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This article is published in The New England Journal of Medicine.The article was published on 1998-04-30 and is currently open access. It has received 2895 citations till now. The article focuses on the topics: Hepatitis B virus.read more
Citations
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
TL;DR: More efficacious treatments, mass immunization programs, and safe injection techniques are essential for eliminating HBV infection and reducing global HBV‐related morbidity and mortality.
CLINICAL-LIVER, PANCREAS, AND BILIARY TRACT Predicting Cirrhosis Risk Based on the Level of Circulating Hepatitis B Viral Load
Uchenna H. Iloeje,Jun Su +1 more
TL;DR: The data show that progression to cirrhosis in hepatitis B-infected persons is correlated strongly with the level of circulating virus and is independent of hepatitis B e-antigen status and serum alanine transaminase level.
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Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update.
Yun Fan Liaw,Jia-Horng Kao,Teerha Piratvisuth,Henry Lik-Yuen Chan,Rong-Nan Chien,Chun-Jen Liu,Edward Gane,Stephen Locarnini,Seng Gee Lim,Kwang Hyub Han,Deepak Amarapurkar,Graham Cooksley,Wasim Jafri,Rosmawati Mohamed,Jin Lin Hou,Wan-Long Chuang,Laurentius A. Lesmana,Jose D. Sollano,Dong Jin Suh,Masao Omata +19 more
TL;DR: New HBV management guidelines include general management, indications for fibrosis assessment, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy.
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The global burden of liver disease: The major impact of China
TL;DR: The epidemiology and characteristics of liver diseases and liver‐related research in China are discussed and many challenges remain that must be tackled collaboratively.
References
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Hepatitis B virus infection.
TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
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Hepatitis B virus persistence after recovery from acute viral hepatitis.
TL;DR: The results suggest that HBV DNA, and possibly HBV virions, can be present in the serum, and that the viral genome can persist in a transcriptionally active form in PBMC for > 5 yr after complete clinical and serological recovery from acute viral hepatitis.
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Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection.
Richard Gilson,A. E. Hawkins,Michael R. Beecham,Emma Z. Ross,J. Waite,Moya Briggs,Tracey McNally,Gabrielle E. Kelly,Richard S. Tedder,Ian V. D. Weller +9 more
TL;DR: The evidence is strengthened for a significant effect of HIV infection on the natural history of chronic HBV infection, which by prolonging the period of infectivity could have an important impact on the epidemiology ofHBV infection in regions, or patient groups, with high HIV seroprevalence.
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Long-lasting memory t cell responses following self-limited acute hepatitis b
Amalia Penna,Marco Artini,A. Cavalli,Massimo Levrero,Antonio Bertoletti,Massimo Pilli,Francis V. Chisari,Barbara Rehermann,G Del Prete,Franco Fiaccadori,Carlo Ferrari +10 more
TL;DR: Results show that vigorous anti-viral T cell responses are detectable in vitro several years after clinical recovery from acute hepatitis B, suggesting that long-term maintenance of an active anti-Viral Tcell response could be important not only for protection against reinfection but also for keeping the persisting virus under tight control.
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"Occult" hepatitis B virus as source of infection in liver transplant recipients
Oliver Chazouilleres,D. Mamish,Mi-Ok Kim,K. Carey,Teresa L. Wright,Linda D. Ferrell,John P. Roberts,Nancy L. Ascher +7 more
TL;DR: The findings do underscore the clinical relevance of HBV infection in the absence of serological markers, and may underscore the need to further investigate the origin of such infections in patients in a California transplantation programme.