Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
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Cites background from "Hepatitis B virus X protein (HBx)-r..."
...LncRNAs are aberrantly expressed in multiple human cancers, such as colorectal, prostate, breast, liver, brain cancer, renal, and bladder cancer, where they may modulate numerous hallmarks to promote or inhibit CRC development, invasion, and metastasis including proliferation, apoptosis, metastasis and metabolism [15-19]....
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"Hepatitis B virus X protein (HBx)-r..." refers background in this paper
...Unlike messenger RNAs (mRNAs), which have to conserve codon use and prevent frameshift mutations in a single long ORF, selection may conserve only short regions of lncRNAs that are constrained by structure or sequence-specific interactions.(29) Because our differentially expressed lncRNAs were derived from the mice microarray data, many of them do not have a homolog gene in the human genome....
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Additional excerpts
...Recent studies have reported that lncRNAs typically function by binding to specific protein partners, serving key regulatory roles to influence the activity and localization of the proteins they bind.(17) Therefore, to investigate whether lncRNA-Dreh functions through this mechanism, we performed an RNA pull-down assay to identify proteins that associated with Dreh (Fig....
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"Hepatitis B virus X protein (HBx)-r..." refers background in this paper
...Long noncoding RNAs (lncRNAs) are a class of noncoding RNA transcripts longer than 200 nucleotides with little or no protein-coding capacity.(7) Recent reports have demonstrated that lncRNAs have a very important role in epigenetic regulation....
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