Hepatitis E Virus Infection
Nassim Kamar,Nassim Kamar,Harry R. Dalton,Florence Abravanel,Florence Abravanel,Jacques Izopet,Jacques Izopet +6 more
Reads0
Chats0
TLDR
In this comprehensive review, the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries are summarized.Abstract:
Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries.read more
Citations
More filters
Journal ArticleDOI
The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
Jeffrey D. Stanaway,Abraham D. Flaxman,Mohsen Naghavi,Christina Fitzmaurice,Christina Fitzmaurice,Theo Vos,Ibrahim Abubakar,Laith J. Abu-Raddad,Reza Assadi,Neeraj Bhala,Neeraj Bhala,Benjamin C Cowie,Mohammad H. Forouzanfour,Justina Groeger,Khayriyyah Mohd Hanafiah,Khayriyyah Mohd Hanafiah,Kathryn H. Jacobsen,Spencer L. James,Jennifer H MacLachlan,Reza Malekzadeh,Natasha K. Martin,Natasha K. Martin,Ali A. Mokdad,Ali H. Mokdad,Christopher J L Murray,Dietrich Plass,Saleem M Rana,David B. Rein,Jan Hendrik Richardus,Juan Sanabria,Juan Sanabria,Mete Saylan,Saeid Shahraz,Samuel So,Vasiliy Victorovich Vlassov,Elisabete Weiderpass,Steven T. Wiersma,Mustafa Z. Younis,Chuanhua Yu,Maysaa El Sayed Zaki,Graham S Cooke +40 more
TL;DR: The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
Journal ArticleDOI
Approved Antiviral Drugs over the Past 50 Years
TL;DR: This paper presents for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide.
Journal ArticleDOI
EASL Clinical Practice Guidelines on hepatitis E virus infection
Harry R. Dalton,Nassim Kamar,Sally A. Baylis,Darius Moradpour,Heiner Wedemeyer,Francesco Negro +5 more
TL;DR: These Clinical Practice Guidelines will be on HEV genotype 3 (and 4) and show that locally acquired HEV is now the commonest cause of acute viral hepatitis in many European countries.
Journal ArticleDOI
A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology
J. Michael Miller,Matthew J. Binnicker,Sheldon Campbell,Karen C. Carroll,Kimberle C. Chapin,Peter H. Gilligan,Mark D. Gonzalez,Robert C. Jerris,Sue C. Kehl,Robin Patel,Bobbi S. Pritt,Sandra S. Richter,Barbara Robinson-Dunn,Joseph D. Schwartzman,James W. Snyder,Sam R. Telford,Elitza S. Theel,Richard B. Thomson,Melvin P. Weinstein,Joseph D. Yao +19 more
TL;DR: This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions.
Journal ArticleDOI
Hepatitis E virus infection.
Nassim Kamar,Jacques Izopet,Nicole Pavio,Rakesh Aggarwal,Alain B. Labrique,Heiner Wedemeyer,Harry R. Dalton +6 more
TL;DR: HEV infections can be diagnosed by measuring anti-HEV antibodies, HEV RNA or viral capsid antigen in blood or stool and management of immunocompromised individuals involves lowering the dose of immunosuppressive drugs and/or treatment with the antiviral agent ribavirin.
References
More filters
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome.
Albert W. Tam,Matthew M. Smith,Martha E. Guerra,Chiao Chain Huang,Daniel W. Bradley,Kirk E. Fry,Gregory R. Reyes +6 more
TL;DR: Findings on the genetic organization and expression strategy of HEV suggest that it is the prototype human pathogen for a new class of RNA virus or perhaps a separate genus within the Caliciviridae family.
Journal ArticleDOI
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
Jordan J. Feld,Jay H. Hoofnagle +1 more
TL;DR: A better understanding of the mechanism of action of IFN and ribavirin will be essential to optimize current therapeutic strategies and to develop new therapies.
Journal ArticleDOI
Zoonotic transmission of hepatitis E virus from deer to human beings
TL;DR: Findings provide direct evidence for HEV infection to be a zoonosis among people who had eaten uncooked deer meat 6-7 weeks before and patients' family members who ate none or very little of the deer meat remained uninfected.