Hepatoprotective effect of amoora rohituka
01 Dec 1997-Vol. 35, Iss: 5, pp 318-322
TL;DR: Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. ro hituka W was studied in rats with hepatic injury induced by carbon tetrachloride and changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A.rohituka suspension.
Abstract: Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. (Meliaceae) was studied in rats with hepatic injury induced by carbon tetrachloride. Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A. rohituka (50 mg/kg/day) was given orally for the same period. The rats were sacrificed 24 h after the last CC14 challenge. Carbon tetrachloride induced elevations of alkaline phosphatase (ALP), glutamate pyruvate transaminase (CPT), alanine aminotransferase (ALAT), glutamate oxaloacetate transaminase (GOT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concentration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension. Changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A. rohituka suspension. These results i...
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TL;DR: The optimum intraperitoneal dose of CCl(4) was found to be 2 ml/kg body weight (dissolved in an equal volume of olive oil), and this increased the level of bilirubin and the activity of the three enzymes significantly, without causing death of the animals.
59 citations
TL;DR: An attempt has been made through this article to review the most potential medicinal plants with pharmacologically established hepatoprotective activity and finds the effective leads from natural resources for the desired therapeutic benefit.
Abstract: Background: Several lead compounds have been developed from natural resources as hepatoprotective. The hepatotoxic nature of the drugs, industrial toxins and drug-induced hepatotoxicity has been recognized as the major problem associated with liver diseases. Natural products including herbs have great potential in treating liver disorders. Objective: Botanicals have been used traditionally by herbalists and indigenous healers worldwide for several years for the prevention and treatment of liver disease and clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Many herbs used in several systems of alternative medicines have a long history of traditional use in revitalizing the liver and treating liver dysfunction and disease. Many of these herbs have been evaluated in clinical studies and are now being investigated phytochemically to understand their actions in a better way. Conclusion: An attempt has been made through this article to review the m...
24 citations
Cites background from "Hepatoprotective effect of amoora r..."
...Caffeic acid [17] Isoquercitrin [18] Quercetin [14]...
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...Changes in the histological architecture of the liver and serum biochemical parameters produced by CCl4 indicated hepatoprotective action [17]....
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Journal Article•
TL;DR: Aphanamixis polystachya (bark) was used as a potential preventive action taken to improve free radical-mediated diseases as discussed by the authors, which is used for the treatment of rheumatism, tumours, liver and spleen diseases.
Abstract: Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Present article highlights an antioxidant activity of a red listed medicinal plant Aphanamixis polystachya bark which has a strong astringent power. It is used for the treatment of rheumatism, tumours, liver and spleen diseases. Antioxidant activity of the crude extracts of A. polystachya (bark) were assessed using DPPH and FRAP assays. The alcohol, aqueous methanol and petroleum ether extracts exhibited potent antioxidant activity compared to known antioxidants. Due to its natural origin and potent free-radical scavenging ability A. Polystachya could be used as a potential preventive action taken to improve free radical-mediated diseases.
18 citations
01 Jan 2012
TL;DR: The zone of inhibitions indicates that the extracts of dried stem bark of Aphanamixis polystachya showed significant antimicrobial activity as comparison to kanamycin.
Abstract: In the present study the bark of Aphanamixis polystachya was investigated for its macroscopic, phytochemical and antimicrobial characteristics. The dried stem bark of A. polystachya was successive extracted with petroleum ether, chloroform, alcoholic and hydromethanolic solvents for 48 hours in soxhlet apparatus and solvents from extracts was evaporated under vacuum. All four extracts were subjected to phytochemical investigation and in vitro antimicrobial screening using different bacterial strains in nutrient agar media. For screening of antimicrobial activity, extracts of dried stem bark of A. polystachya was used at the different doses (10, 20, 50 and 100mg/ml) against the kanamycin, which was used as standard antimicrobial agent at the dose of 30mg/ml. The zone of inhibitions indicates that the extracts of dried stem bark of Aphanamixis polystachya showed significant antimicrobial activity as comparison to kanamycin. The Preliminary phytochemical investigation revealed the presence of various phytoconstituents in each extracts. It showed the presence of carbohydrates, glycosides and saponins.
8 citations
TL;DR: The present review may provide useful evidence for reasonable utilization of Amoora species as folk medicines and further research in drug discovery.
7 citations
References
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Journal Article•
TL;DR: The results suggest that the decrease in the plasma membrane Na+,K+-ATPase activity of the cirrhotic rat is due in part to an increase in its cholesterol concentration and in the cholesterol to phospholipid ratio.
44 citations
TL;DR: Oral administration of Xiao-Chai-Hu-Tang, the extract of a mixture of seven herbs, attenuated the hepatic fibrosis developed in mice after repeated doses of carbon tetrachloride.
35 citations
TL;DR: The findings indicate that the leaf extract of Withania frutescens has both preventative and curative activity against CCL4‐induced liver damage.
Abstract: We studied the protective and curative action of an ethanol extract of Withania frutescens leaves against CCl4-induced hepatotoxicity. Hepatoprotective activity was evaluated in terms of the LD50 of CCl4, the modification of Nembutal-induced sleep, the action on bile flow, serum transaminase and hepatic fatty acids levels and a histopathological study of liver tissue. Curative action was assessed by measuring the duration of Nembutal-induced sleep and with a histopathological study of liver tisue. The findings indicate that the leaf extract has both preventative and curative activity against CCL4-induced liver damage.
35 citations
TL;DR: It is suggested that adrenalectomy and SKF-treatment may interfere with the system responsible for the conversion of CCl4 into an active form, but also that the NADPH-dependent drug-metabolizing enzymes, strongly inhibited by SKF, are not immediately involved in this transformation.
28 citations
TL;DR: Results indicate the hepatoprotective action of the alcohol extract of Chelidonium majus as an antihepatotoxic agent, and significant protection toward CC14-induced elevation of plasma enzymes, changes in bilirubin, cholesterol and liver histology.
Abstract: The efficacy of an alcohol extract of Chelidonium majus as an antihepatotoxic agent was tested on rats with CC14-induced hepatic injury. CCl4 (1 ml/kg; twice a week) and extract (125 mg/kg/day) were administered simultaneously. The parameters studied to assess liver damage were. plasma ALAT, ASAT. AIP, LDH, bilirubin, cholesterol and liver histology. Significant protection toward CC14-induced elevation of plasma enzymes, changes in bilirubin, cholesterol. and microscopic liver damage was observed. These results indicate the hepatoprotective action of the extract.
18 citations