Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management.
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Cites background from "Hepatotoxicity Related to Anti-tube..."
...Genetic and other risk factors affect drug metabolism or clearance enzymes and determine the intracellular concentration of hepatic reactive intermediate [116]....
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...Within the literature, there is a consensus that RMP/INH phase I hepatic metabolism and failure of phase II hepatic elimination leads to toxic accumulation of reactive intermediates [116]....
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...Biotransformation of RMP leads to formation of a reactive toxic intermediate, deacetyl rifampin, which can bind to cellular macromolecules and cause liver injury [116]....
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...Many risk factors such as age, alcohol consumption, gender and underlying diseases such as hepatitis B and C or cirrhosis could make TB patients undergoing anti-TB treatment more susceptible to RMP and INH hepatotoxicity [116-118]....
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Cites background from "Hepatotoxicity Related to Anti-tube..."
...Moreover, NRF2 activation is thought to be the main cause of resistance to chemotherapy and radiotherapy (Ramos-Gomez et al., 2001; Singh et al., 2006; Shibata et al., 2008a; Jiang et al., 2010; Zhang et al., 2010; Zhou et al., 2013; No et al., 2014; Choi and Kwak, 2016; Ryoo et al., 2016)....
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