hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels
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Cites background from "hERG1a and hERG1b potassium channel..."
...IKr channels minimally comprise hERG1a and hERG1b subunits (Sale et al., 2008; Jones et al., 2004), which associate cotranslationally (Phartiyal et al., 2007) and preferentially form heteromultimers (McNally et al., 2017)....
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References
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"hERG1a and hERG1b potassium channel..." refers background in this paper
...Genetic mutations in both human ERG1a and ERG1b subunits are linked to LQT2 (1, 15, 16) indicating the pathophysiological importance of both isoforms. hERG1a and hERG1b are clearly both critical to form IKr and there is some evidence that the subunits co-associate....
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...ERG K channels are expressed in the heart (1, 2), central nervous system (3), and in a variety of other tissues, including tumor cells (4, 5)....
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...ERG1a and ERG1b subunits are linked to LQT2 (1, 15, 16) indi-...
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...longed action potentials that can lead to sudden death (1)....
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1,559 citations
"hERG1a and hERG1b potassium channel..." refers methods in this paper
...Oocytes were injected with hERG channel subunits fused to monomeric, enhanced CFP or monomeric Citrine (26, 38)....
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1,387 citations
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"hERG1a and hERG1b potassium channel..." refers background in this paper
...of IKr in adult mammalian cardiomyocytes (11, 12) and cardiomyocytes derived from human-induced pluripotent stem...
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...cipal ( ) subunits that form the cardiac IKr current (2, 6 –10) whose role is to repolarize action potentials (11, 12)....
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