Journal ArticleDOI
Herpesviruses remodel host membranes for virus egress
David C. Johnson,Joel D. Baines +1 more
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TLDR
This Review describes the remodelling of host membranes that facilitates herpesvirus egress and describes how capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released.Abstract:
Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.read more
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Silver Nanoparticles as Potential Antiviral Agents
Stefania Galdiero,Annarita Falanga,Mariateresa Vitiello,Marco Cantisani,Veronica Marra,Massimiliano Galdiero +5 more
TL;DR: The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.
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The many functions of ESCRTs
Marina Vietri,Marina Vietri,Maja Radulovic,Maja Radulovic,Harald Stenmark,Harald Stenmark,Harald Stenmark +6 more
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Autophagy during viral infection - a double-edged sword
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Applications of gold nanoparticles in virus detection.
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A cost-benefit analysis of the physical mechanisms of membrane curvature
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References
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Journal ArticleDOI
The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.
Duncan J. McGeoch,M. A. Dalrymple,Andrew J. Davison,Aidan Dolan,Margaret C. Frame,David McNab,Lise J. Perry,J. E. Scott,P. Taylor +8 more
TL;DR: In the whole genome of HSV-1 the authors now recognize 72 genes which encode 70 distinct proteins, and the gene layout for UL was found to be very similar to that for the corresponding part of the genome of varicella-zoster virus, the only other completely sequenced alphaherpesvirus.
Journal ArticleDOI
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Thomas Dechat,Katrin Pfleghaar,Kaushik Sengupta,Takeshi Shimi,Dale K. Shumaker,Liliana Solimando,Robert D. Goldman +6 more
TL;DR: An up-to-date overview of the functions of nuclear lamins is provided, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair.
Journal ArticleDOI
Infections with herpes simplex viruses (1).
Lawrence Corey,Patricia G. Spear +1 more
TL;DR: This review concludes that there have been substantial advances in the knowledge of the clinical manifestations, pathogenesis, and treatment of herpes simplex virus infections in the 12 years since the last review.
Journal ArticleDOI
Herpesvirus Assembly and Egress
TL;DR: Findings are focused on recent findings that demonstrate a rather complex process of herpesvirus maturation including primary envelopment of capsids by budding at the inner leaflet of the nuclear membrane and translocation of capsid into the cytoplasm after loss of the primary envelope by fusion with the outer leaflets of thenuclear membrane.
Journal ArticleDOI
Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome
Susan M. Varnum,Daniel N. Streblow,Matthew E. Monroe,Patricia P. Smith,Kenneth J. Auberry,Ljiljana Paša-Tolić,Dai Wang,David G. Camp,Karin D. Rodland,Steven Wiley,William J. Britt,Thomas Shenk,Richard D. Smith,Jay A. Nelson +13 more
TL;DR: 71 HCMV-encoded proteins that included 12 proteins encoded by known viral open reading frames previously not associated with virions and 12 proteins from novel viral ORFs are identified.