Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel
TL;DR: In this paper, the Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.
Abstract: Aliphatische Ketone, Aldehyde sowie β-Dicarbonylverbindungen reagieren mit methylenaktiven Nitrilen und Schwefel in Gegenwart von Aminen bei Raumtemperatur zu 2-Aminothiophenen. — Eine Variante der Synthese, die Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.
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TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
Abstract: Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting materials, e.g. 3, 4, … 7, where most of the atoms of the starting materials are incorporated in the final product.1 Several descriptive tags are regularly attached to MCRs (Fig. 1): they are atom economic, e.g. the majority if not all of the atoms of the starting materials are incorporated in the product; they are efficient, e.g. they efficiently yield the product since the product is formed in one-step instead of multiple sequential steps; they are convergent, e.g. several starting materials combine in one reaction to form the product; they exhibit a very high bond-forming-index (BFI), e.g. several non-hydrogen atom bonds are formed in one synthetic transformation.2 Therefore MCRs are often a useful alternative to sequential multistep synthesis.
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Figure 1
Above: multistep syntheses can be divergent (sequential) or convergent; below: in analogy MCR reactions are convergent and one or two component reactions are divergent or less convergent.
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TL;DR: In this article, the synthesis, properties and application of azo disperse dyes prepared from diazo components containing aromatic heterocycles are discussed, and azo dispersions are discussed.
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TL;DR: In this paper, the authors present the most elegant and promising set of synthetic routes for the synthesis of 2-aminothiophenes by the Gewald reaction applications of this facile methodology to pharmaceuticals and dyestuffs have been demonstrated
265 citations
TL;DR: In this paper, a review summarizes the advances from 2000 in the construction of organic molecules using elemental sulfur via sulfuration, oxidation, reduction, and redox condensation processes, and concludes that the use of elemental sulfur has been known since Antiquity and found widespread applications in the preparation of black gunpowder, the synthesis of sulfuric acid as well as other sulfur-containing compounds.
Abstract: Elemental sulfur has been known since Antiquity and found widespread applications in the preparation of black gunpowder, the synthesis of sulfuric acid as well as other sulfur-containing compounds, and the vulcanization of rubber. Over the last several years, we have come to better understand its properties and discover more applications of elemental sulfur in synthetic organic chemistry. This review summarizes the advances from 2000 in the construction of organic molecules using elemental sulfur via sulfuration, oxidation, reduction and redox condensation processes.
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TL;DR: A Bayesian computational model was developed using tetrahydrobenzothiophene structure-activity data, yielding insight into the physical character and structural features of active and inactive potentiators and successfully predicting the activity of structural analogs.
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TL;DR: In this paper, the α-Oxo-mercaptane reagieren mit Nitrilen, die in α-Stellung eine aktive Methylengruppe besitzen, basenkatalysiert zu 2.3.
Abstract: α-Oxo-mercaptane reagieren mit Nitrilen, die in α-Stellung eine aktive Methylengruppe besitzen, basenkatalysiert zu 2-Amino-thiophenen. Diese entstehen auch bei der Einwirkung von Natriumhydrogensulfid auf bestimmte 2.3.4-trisubstituierte 4-Halogen-crotonsaurenitrile.
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