HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance
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Cites background from "HIF-1–Dependent Stromal Adaptation ..."
...In addition, high expression of HIF-1α is related to resistance to chemotherapy [30] and radiation therapy [31]....
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3 citations
Additional excerpts
...n= 63 (%) Tumor outside CTV n=9 (%) Tumor within CTV n=54 (%) Histopathological T-stage ypT0 15 (24) 1 (11) 14 (27) ypT1 12 (19) 0 (0) 12 (22) ypT2 9 (14) 2 (22) 7 (13) ypT3 27 (43) 6 (67) 21 (38) ypT4 0 (0) 0 (0) 0 (0)...
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Cites background from "HIF-1–Dependent Stromal Adaptation ..."
...Likely reasons for this radioresistance include the proposed mechanism of reactions with oxygen radicals causing and stabilizing radiation-caused DNA damage [80] as well a post-radiation HIF-driven response that promotes tumor growth and angiogenesis [81]....
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References
6,024 citations
"HIF-1–Dependent Stromal Adaptation ..." refers background in this paper
...Given prosurvival and angiogenic effects of HIF-1, targeted inhibition of HIF-1 signaling has generated interest as a target for therapeutic modulation of radioresistance (5)....
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4,773 citations
"HIF-1–Dependent Stromal Adaptation ..." refers methods in this paper
...This initial registration was then further refined through the multiresolution iterative maximization of a normalized mutual information cost function (18)....
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3,300 citations
"HIF-1–Dependent Stromal Adaptation ..." refers background in this paper
...Tumor vessels are distinct from their normal counterparts by virtue of their dependence on prosurvival stimulatory cytokines such as VEGF (8)....
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2,328 citations
"HIF-1–Dependent Stromal Adaptation ..." refers background in this paper
...HIF-1– stimulated tumor expression of VEGF and other proangiogenic factors is key to this process (27)....
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