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High prevalence of headaches in patients with epilepsy

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TLDR
The high prevalence of postictal headaches confirms the frequent triggering of a headache by a seizure, a condition in which the real triggering effect of the headache on the seizure might be difficult to prove.
Abstract
To examine the association between headaches and epilepsy. Consecutive adult epileptic patients who went to the outpatient clinic of the Epilepsy Center of PLA General Hospital between February 01, 2012, and May 10, 2013, were recruited into this study. A total of 1109 patients with epilepsy completed a questionnaire regarding headaches. Overall, 60.1% of the patients (male: 57.2%; female: 63.8%) reported headaches within the last year. The age-weighted prevalence of interictal migraine was 11.7% (male 8.9%, female 15.3%), which is higher than that reported in a large population-based study (8.5%, male 5.4%, female 11.6%) using the same screening questions. The prevalence of postictal headaches was 34.1% (males 32.7%, females 35.2%), and the presence of preictal headaches was 4.5% (males 4.3%, females 5.2%). The prevalence of headache yesterday in the general population was 4.8% (male 3.0%, female 6.6%). Thus, the prevalence of headaches, including migraine, is higher in epileptic patients in China. The high prevalence of postictal headaches confirms the frequent triggering of a headache by a seizure. A much lower frequency of preictal headaches, a condition in which the real triggering effect of the headache on the seizure might be difficult to prove.

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Journal ArticleDOI

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

TL;DR: This study examined which 5-HT receptor subtypes can be targeted to trigger antiseizure effects in homozygous scn1Lab(-/-) mutant zebrafish larvae that recapitulate DS well and confirmed the efficacy of fenfluramine as an antiepileptiform compound in zebra fish models of DS.
Journal ArticleDOI

Pathophysiological Bases of Comorbidity in Migraine.

TL;DR: In this paper, the authors proposed a multidisciplinary approach to identify and eliminate possible risk and comorbidity factors for the treatment of migraine, which is designed to maintain brain homeostasis by regulating homeostatic needs such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response.
Journal ArticleDOI

Epilepsy and headaches: Further evidence of a link

TL;DR: It is suggested that headaches, particularly migraine-type headaches, were frequently experienced by patients with epilepsy, postictal headaches were more common, and the frequency of migraine attacks could be linked with seizure frequency and the type of treatment.
Journal ArticleDOI

Prodrome in epilepsy.

TL;DR: Prodromes are characterized by a broad spectrum of preictal symptoms that may be experienced for a duration of between 10min and several days, which usually persist until seizure onset, and usually persist for between 30min and 24h.
References
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Journal ArticleDOI

The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide:

TL;DR: The calculations indicate that the disability attributable to tension-type headache is larger worldwide than that due to migraine, which would bring headache disorders into the 10 most disabling conditions for the two genders, and into the five most disabling for women.
Journal ArticleDOI

Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors.

TL;DR: The magnitude and distribution of the public health problem posed by migraine in the United States is described by examining migraine prevalence, attack frequency, and attack-related disability by gender, age, race, household income, geographic region, and urban vs rural residence.
Journal ArticleDOI

Epidemiology of headache.

BK Rasmussen
- 01 Sep 2001 - 
TL;DR: The study supports the notion that migraine and tension-type headache are separate clinical entities and that migraine without aura and migraine with aura are distinct subforms of migraine.
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