High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lomé, Togo
Anoumou Y. Dagnra,Nicole Vidal,Akovi Mensah,Akouda Patassi,Komi Aho,Mounerou Salou,Marjorie Monleau,Mireille Prince-David,Assétina Singo,Palokinam Pitché,Eric Delaporte,Martine Peeters +11 more
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TLDR
The high number of resistant strains observed in Togo shows clearly that the emergence of HIV drug resistance is of increasing concern in countries where ART is now widely used, and can compromise the long-term success of first- and second-line ART.Abstract:
With widespread use of antiretroviral (ARV) drugs in Africa, one of the major potential challenges is the risk of emergence of ARV drug-resistant HIV strains. Our objective is to evaluate the virological failure and genotypic drug-resistance mutations in patients receiving first-line highly active antiretroviral therapy (HAART) in routine clinics that use the World Health Organization public health approach to monitor antiretroviral treatment (ART) in Togo.read more
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Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review.
TL;DR: The emergence of drug resistance following access to ART in resource-limited settings resembles what was seen inresource-rich countries and highlights the need for virological monitoring for drug failure, drug resistance testing and alternative drug regimens that have proven beneficial in these resource-rich settings.
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Extraordinary Heterogeneity of Virological Outcomes in Patients Receiving Highly Antiretroviral Therapy and Monitored With the World Health Organization Public Health Approach in Sub-Saharan Africa and Southeast Asia
Avelin F. Aghokeng,Marjorie Monleau,Sabrina Eymard-Duvernay,Anoumou Dagnra,Dramane Kania,Nicole Ngo-Giang-Huong,Thomas d. 'Aquin Toni,Coumba Toure-Kane,Lien X. T. Truong,Eric Delaporte,Marie-Laure Chaix,Martine Peeters,Ahidjo Ayouba +12 more
TL;DR: The findings show heterogeneous virological failure and illustrate that, in addition to routine access to viral load, good management of ART programs is even more critical to improve treatment outcomes in resource-limited countries.
Journal ArticleDOI
The origin and molecular epidemiology of HIV
TL;DR: The genetic diversity of HIV-1 continues to increase overtime due to demographic factors such as travel and migration and frequent co/superinfections, which leads to an increasing number of drug-resistant strains, especially in resource limited countries.
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Virological failure rates and HIV-1 drug resistance patterns in patients on first-line antiretroviral treatment in semirural and rural Gabon
Florian Liegeois,Caroline Vella,Sabrina Eymard-Duvernay,Jeanne Sica,Laurent Makosso,Augustin Mouinga-Ondémé,Arnaud Delis Mongo,Vanina Boué,Christelle Butel,Martine Peeters,Jean-Paul Gonzalez,Eric Delaporte,François Rouet +12 more
TL;DR: As antiretroviral treatment (ART) continues to expand in resource‐limited countries, the emergence of HIV drug resistance mutations (DRMs) is challenging in these settings.
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Persistent Difficulties in Switching to Second-Line ART in Sub-Saharan Africa — A Systematic Review and Meta-Analysis
TL;DR: The low incidence rate of switching to second-line ART in sub-Saharan Africa suggests that the monitoring of patients under ART is challenging and that access to second -line ART is ineffective; efforts should be made to increase access toSecond- line ART to those in need by providing monitoring tools, education and training, as well as a more convenient regimen.
References
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TL;DR: Reports from resource-limited countries suggest that initial ART programmes are as effective as in resource-rich countries, which should limit HIV drug resistance if programme effectiveness continues during scale-up.