High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lomé, Togo
Anoumou Y. Dagnra,Nicole Vidal,Akovi Mensah,Akouda Patassi,Komi Aho,Mounerou Salou,Marjorie Monleau,Mireille Prince-David,Assétina Singo,Palokinam Pitché,Eric Delaporte,Martine Peeters +11 more
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TLDR
The high number of resistant strains observed in Togo shows clearly that the emergence of HIV drug resistance is of increasing concern in countries where ART is now widely used, and can compromise the long-term success of first- and second-line ART.Abstract:
With widespread use of antiretroviral (ARV) drugs in Africa, one of the major potential challenges is the risk of emergence of ARV drug-resistant HIV strains. Our objective is to evaluate the virological failure and genotypic drug-resistance mutations in patients receiving first-line highly active antiretroviral therapy (HAART) in routine clinics that use the World Health Organization public health approach to monitor antiretroviral treatment (ART) in Togo.read more
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Journal ArticleDOI
Dried blood spots for HIV‐1 drug resistance genotyping in decentralized settings in Senegal
Abou Abdallah Malick Diouara,Halimatou Diop-Ndiaye,Khady Kébé-Fall,Edmond Tchiakpe,Ousseynou Ndiaye,Ahidjo Ayouba,Martine Peeters,Souleymane Mboup,Coumba Toure Kane +8 more
TL;DR: Evaluated the use for HIV‐1 drug resistance testing dried blood spots collected in remote areas and sent under field conditions to a reference laboratory and also to document virological failure in patients with suspected treatment failure, finding use of a DBS specimen is suitable to assist national programs for monitoring inRemote areas.
Journal ArticleDOI
Single Real-Time Reverse Transcription-PCR Assay for Detection and Quantification of Genetically Diverse HIV-1, SIVcpz, and SIVgor Strains
Lucie Etienne,Sabrina Eymard-Duvernay,Avelin F. Aghokeng,Christelle Butel,Marjorie Monleau,Martine Peeters +5 more
TL;DR: A real-time reverse transcription-PCR assay that is relatively inexpensive and able to detect and quantify all circulating forms of HIV-1 and its simian immunodeficiency virus (SIV) precursors, SIVcpz and SIVgor, which can therefore be useful in geographical areas of high HIV diversity and at risk for the emergence of new HIV variants.
Journal ArticleDOI
Virological success after 12 and 24 months of antiretroviral therapy in sub-Saharan Africa: Comparing results of trials, cohorts and cross-sectional studies using a systematic review and meta-analysis.
TL;DR: Evidence from this review suggests that the new international target of 90% of patients controlled is not yet being achieved, and that in order to improve the virological outcome, efforts should be made to improve retention in care.
Dissertation
Utilisation du modèle CEPAC en appui à la recherche clinique dans le domaine de la prise en charge des adultes infectés par le VIH en Afrique sub-saharienne
TL;DR: This article found that beaucoup of questions de recherche n’ont pas ete explorees par des essais, soit parce qu’un essai pour repondre a question n'etait pas juge possible, and that les essais ayant des resultats positifs debouchent souvent eux meme sur de nouvelles questions, notamment sur l’interpretation a leurs resultats, les implications pratiques, les projections a long terme, and la replicabilite
Journal ArticleDOI
Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo.
Yawo Tufa Nyasenu,Fifonsi Adjidossi Gbeasor-Komlanvi,Amivi Ehlan,Sabi Abdul-Raouf Issa,Sika Dossim,Malewe Kolou,Brice Martial Yambiyo,Mireille Prince-David,Mounerou Salou,Didier K. Ekouevi,Anoumou Dagnra +10 more
TL;DR: This study showed the diversity of circulating HPV genotypes in Togo and programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities.
References
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