High prevalence of hyposalivation in individuals with neurofibromatosis 1: a case-control study
Karin Soares Gonçalves Cunha,Rafaela Elvira Rozza-De-Menezes,Eloá Borges Luna,Lilian Machado De Sousa Almeida,Raquel Richelieu Lima De Andrade Pontes,Paula Nascimento Almeida,Letícia Vidaurre de Aguiar,Eliane Pedra Dias +7 more
Reads0
Chats0
TLDR
Hyposalivation may be a consequence of NF1, as occurs in other genetic diseases, and more studies are necessary to understand if there is and what is the relationship between NF1 and hyposalivation.Abstract:
Background
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases in humans and has widely variable expressivity. Oral manifestations are common, but there are no studies that investigated functional alterations in salivary glands in NF1. Our aim was to evaluate the salivary flow rate in NF1 individuals, comparing to a control group, and to investigate the possible causes and some consequences of salivary gland alteration.read more
Citations
More filters
Journal ArticleDOI
World Workshop on Oral Medicine VIII: development of a core outcome set for dry mouth: A systematic review of outcome domains for xerostomia.
Paswach Wiriyakijja,Sven Niklander,Alan Roger Santos-Silva,Michal Kuten Shorrer,Melanie Simms,Alessandro E. P. Villa,Vidya Sankar,Alexander Ross Kerr,Richeal Ni Riordain,Siri Beier Jensen,Konstantina Delli +10 more
TL;DR: This paper identified all outcome domains used in clinical studies of xerostomia, that is, subjective sensation of dry mouth, and mapped them to the Core Outcome Measures in Effectiveness Trials taxonomy.
Journal ArticleDOI
World Workshop on Oral Medicine VIII: development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunction.
Melanie Simms,Michal Kuten-Shorrer,Paswach Wiriyakijja,Sven Niklander,Alan Roger Santos-Silva,Vidya Sankar,Alexander Ross Kerr,Siri Beier Jensen,Richeal Ni Riordain,Konstantina Delli,Alessandro E. P. Villa +10 more
TL;DR: A systematic review including clinical trials and prospective or retrospective observational studies involving human participants with dry mouth, with any type of intervention where the objective assessment of salivary gland hypofunction was described was described as discussed by the authors .
Type 1neurofibromatosis and effects on the stomatognatic system
TL;DR: The goal of this research was to understand the way type I neurofibromatosis can affect the oral cavity and how the dental doctor can help.
Journal ArticleDOI
Reliability, Accuracy, and Use Frequency of Evaluation Methods for Amount of Tongue Coating
Su-Ryun Kim,Dong-Hyun Nam +1 more
TL;DR: The high prevalence of the specificative method would continue in clinical practice because of its convenience and accuracy, however, to establish higher reliability, the limitation of the subjectivity of the assessors should be overcome through calibration training.
Journal ArticleDOI
Oral Clinical Manifestations of Neurofibromatosis Type 1 in Children and Adolescents
Rossella Santoro,Claudia Santoro,Francesca Loffredo,Antonio Romano,Silverio Perrotta,Rosario Serpico,Dorina Lauritano,Alberta Lucchese +7 more
TL;DR: It can be stated that NF1-related oral manifestations can be detected during childhood and adolescence, in particular for neurofibromas, enamel defects, shape anomalies, and poor oral hygiene.
References
More filters
Journal ArticleDOI
National Institutes of Health Consensus Development Conference Statement: Geriatric Assessment Methods for Clinical Decision‐making
A. Sue Brown,Kenneth Brummel-Smith,Lavola Burgess,Ralph B. D'Agostino,John W. Goldschmidt,Jeffrey B. Halter,William R. Hazzard,Dennis W. Jahnigen,Charles Phelps,Murray A. Raskind,Robert W. Schrier,Harold C. Sox,Sankey V. Williams,May Wykle +13 more
TL;DR: To deal with the exceedingly difficult health care issues posed by frail elderly persons, health professionals need to collect, organize, and use a vast array of clinically relevant information.
A case report and literature review
TL;DR: The Plummer-Vinson syndrome has come increasingly rare with the availabil¬ ity of iron supplements, but nonetheless it should be suspected in the setting of dysphagia and iron deficiency.
Journal ArticleDOI
Neurofibro matosis: Oral and radiographic manifestations
Steven D. Shapiro,Steven D. Shapiro,Kenneth Abramovitch,Kenneth Abramovitch,Margot L. Van Dis,Margot L. Van Dis,Larry J. Skoczylas,Larry J. Skoczylas,Robert P. Langlais,Robert P. Langlais,Ronald J. Jorgenson,Ronald J. Jorgenson,Robert S. Young,Robert S. Young,Vincent M. Riccardi,Vincent M. Riccardi +15 more
TL;DR: The prevalence of oral and radiographic findings in this sample was 72%, which is much higher than previously reported and the five most common findings are oral neurofibromas, enlarged fungiform papillae, intrabony lesions, wide inferior alveolar canals, and enlarged mandibular foramina.
Journal ArticleDOI
Tongue coating and salivary bacterial counts in healthy/gingivitis subjects and periodontitis patients
TL;DR: No relationship between the appearance of the tongue and salivary bacterial load could be detected and there was no difference in bacterial load between the healthy/gingivitis and the periodontitis group within the present study population.
Journal ArticleDOI
Neurofibromatosis 1 (NF1) mRNAs expressed in the central nervous system are differentially spliced in the 5′ part of the gene
TL;DR: Evidence of alternative splicing in this region of the NF1 gene is identified using reverse transcription-polymerase chain reaction (RT-PCR) analyses with primers located in exons 7 and 13, and an isoform bearing an extra 30 bp sequence between exons 9 and 10a is proposed to be called exon 9br.