High-Resolution Genomic Profiling of Disseminated Tumor Cells in Prostate Cancer
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Cites background from "High-Resolution Genomic Profiling o..."
...components such as tumor DNA (ctDNA) has allowed investigators to detect tumors, often before the appearance of clinical symptoms, as well as to provide physicians with the means to follow tumor changes, including progression [44]....
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References
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"High-Resolution Genomic Profiling o..." refers background in this paper
...The forkhead box protein family members are transcription factors that bind to AR and regulate its association with androgen response elements.(26) FOXO proteins have tumor suppressor activity....
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"High-Resolution Genomic Profiling o..." refers methods in this paper
...Among techniques that help define the alterations present in all tumor subpopulations, methods to detect and isolate tumor cells from the blood or bone marrow of cancer patients provide new and relatively noninvasive alternatives for sampling solid tumors and are referred to as liquid biopsies.(1) Circulating tumor cells (CTCs) are shed from tumors into the blood and provide an index of the current tumor burden....
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"High-Resolution Genomic Profiling o..." refers methods in this paper
...Probe re-centering was based on the genomic median of all probes or with the use of the ASCAT algorithm.(19) Thresholds for calling CN alterations were as follows: high copy gain 0....
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