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Higher Platelet Count is Associated with First Episode of Peritonitis Risk in Incident Peritoneal Dialysis Patients

22 May 2023-
TL;DR: A Cox regression analysis was used to evaluate the independent association of platelet count with the occurrence of peritoneal dialysis-associated peritonitis as discussed by the authors , which was a retrospective, observational, single-center cohort study, where the authors were adjusted for gender, age, BMI, cardiovascular disease, diabetes mellitus, white blood cell, neutrophil-lymphocyte ratio, hemoglobin, albumin, potassium and antiplatelet medication usage.
Abstract: Abstract Platelets play parts in infection, inflammation, and immune processes. However, the association between platelet count and the risk of peritoneal dialysis-associated peritonitis is unclear. This was a retrospective, observational, single-center cohort study. A Cox regression analysis was used to evaluate the independent association of platelet count with the occurrence of first PD-associated peritonitis. Models were adjusted for gender, age, BMI, cardiovascular disease, diabetes mellitus, white blood cell, neutrophil-lymphocyte ratio, hemoglobin, albumin, potassium, and anti-platelet medication usage. A total of 2374 patients were enrolled in this study (59% men; mean age 47.40 ± 12.12). The average platelet count was 229.30 ± 82.12 x 10 9 /L. 467 (20%) patients suffered from PD-associated peritonitis at least once. In the multivariable model, the adjusted hazard ratios (HRs) for quartiles 2, 3, and 4 versus quartile 1 were 1.391 (95% CI 0.984–1.996, P = 0.062), 1.835 (95% CI 1.316–2.558, P < 0.001), and 1.919 (95% CI 1.356–2.715, P < 0.001) with baseline data. A nonlinear relationship between platelet count and first PD-associated peritonitis was observed. Further, the association between platelet and first PD-associated peritonitis was significant in the patients with hypokalemia ( P for interaction = 0.040). In PD patients, elevated platelet counts were significantly associated with an increased risk of the first onset of PD-associated peritonitis.

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References
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Journal ArticleDOI
29 Jan 2010-Science
TL;DR: A previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases is demonstrated and the collagen receptor glycoprotein VI is identified as a key trigger for platelet microparticle generation in arthritis pathophysiology.
Abstract: In addition to their pivotal role in thrombosis and wound repair, platelets participate in inflammatory responses. We investigated the role of platelets in the autoimmune disease rheumatoid arthritis. We identified platelet microparticles—submicrometer vesicles elaborated by activated platelets—in joint fluid from patients with rheumatoid arthritis and other forms of inflammatory arthritis, but not in joint fluid from patients with osteoarthritis. Platelet microparticles were proinflammatory, eliciting cytokine responses from synovial fibroblasts via interleukin-1. Consistent with these findings, depletion of platelets attenuated murine inflammatory arthritis. Using both pharmacologic and genetic approaches, we identified the collagen receptor glycoprotein VI as a key trigger for platelet microparticle generation in arthritis pathophysiology. Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases.

986 citations

Journal ArticleDOI
TL;DR: Peritonitis remains a leading complication of peritoneal dialysis, and sometimes is associated with death of the patient, and the PD community continues to focus attention on prevention and treatment of PD-related infections.
Abstract: Peritonitis remains a leading complication of peritoneal dialysis (PD). It contributes to technique failure and hospitalization, and sometimes is associated with death of the patient. Severe and prolonged peritonitis can lead to peritoneal membrane failure. Therefore, the PD community continues to focus attention on prevention and treatment of PD-related infections.

662 citations

Journal ArticleDOI
01 Nov 2001-Blood
TL;DR: A novel pathway of TPO regulation by the inflammatory mediator IL-6 is proposed, indicating that the number of platelets by themselves might not be the sole determinant of circulating TPO levels and thus of thrombopoiesis.

547 citations

Journal ArticleDOI
10 Sep 2020-Blood
TL;DR: It is demonstrated that increased platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in patients presenting mild CO VID-19 syndrome, and these data shed light on new pathological mechanisms involving plateletactivation and Platelet-dependent monocyte TF expression, which were associated with COVID -19 severity and mortality.

500 citations

Journal ArticleDOI
TL;DR: Evidence of beneficial effects of metabolic control on platelet function is strengthened by the results of clinical trials documenting the beneficial effects, and by the finding that aspirin treatment may even be more beneficial in diabetic than in high‐risk non‐diabetic patients.

416 citations