Journal ArticleDOI
Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
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TLDR
Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.About:
This article is published in Organic Letters.The article was published on 2005-04-14. It has received 862 citations till now. The article focuses on the topics: Cinchona Alkaloids & Michael reaction.read more
Citations
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Small-molecule H-bond donors in asymmetric catalysis.
Journal ArticleDOI
Asymmetric catalysis by chiral hydrogen-bond donors.
Mark S. Taylor,Eric N. Jacobsen +1 more
TL;DR: This review documents the structural and mechanistic features that contribute to high enantioselectivity in hydrogen-bond-mediated catalytic processes in small-molecule, synthetic catalyst systems.
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Asymmetric Organocatalysis: From Infancy to Adolescence
TL;DR: This Review deals with selected studies reported in 2006 and the first half of 2007, and is intended to highlight four main aspects that may be taken as testimony of the present status and prospective of organocatalysis.
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(Thio)urea organocatalysis—What can be learnt from anion recognition?
Zhiguo Zhang,Peter R. Schreiner +1 more
TL;DR: The present critical review outlines the close relationship and mutual interplay between molecular recognition, active site considerations in enzyme catalysis involving anions, and organocatalysis utilizing explicit hydrogen bonding.
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Chalcone: A Privileged Structure in Medicinal Chemistry.
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
References
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Encoding and decoding hydrogen-bond patterns of organic compounds
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In the Golden Age of Organocatalysis
Peter I. Dalko,Lionel Moisan +1 more
TL;DR: The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose "Golden Age" has already dawned.
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Asymmetric Organic Catalysis with Modified Cinchona Alkaloids
TL;DR: These studies demonstrate the potential of modified cinchona alkaloids as broadly useful chiral organic catalysts for asymmetric synthesis.
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Conjugate Additions of Nitroalkanes to Electron-Poor Alkenes: Recent Results
TL;DR: This review is focused on the utilization of nitroalkanes as nucleophiles in conjugate additions with electron-poor alkenes and covers the new procedures and related applications appearing in the literature after 1990.