Highly improved adsorption selectivity of L-phenylalanine imprinted polymeric submicron/nanoscale beads prepared by modified suspension polymerization
TL;DR: In this article, the effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied.
Abstract: Molecularly imprinted polymer (MIP) submicron/nanoscale beads selective for L-Phenylalanine (L-Phe) and D-Phe as well as non-imprinted beads were prepared by modified suspension polymerization involving agitation of the reaction mixture at high rotation speed under safe radical conditions. The effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied. L-Phe-imprinted submicron/nanoscale beads prepared for the first time by modified suspension polymer- ization showed enhanced adsorption capacity and selectivity over those of D-Phe imprinted and non-imprinted beads. Maximum adsorption capacity, 0.35 mg/g, and selectivity, 1.62, of L-Phe imprinted submicron/nanoscale beads were higher than the adsorption capacities, 0.30 and 0.19 mg/g, and selectivities, 1.59 and 1.02, of D-Phe imprinted and non- imprinted submicron/nanoscale beads, respectively. FE-SEM analyses revealed that L- and D-Phe imprinted beads were larger (100 nm-1.5 µm) than non-imprinted nanobeads (100-800 nm). 13 C CP-MAS NMR spectroscopy helped in cor- relating the bead sizes and the extent of reaction during polymerization. Similarly, FT-IR study was used for evaluation of structural characteristics of the prepared Phe-imprinted and non-imprinted beads. The preparation of Phe-imprinted submicron/nanoscale beads with improved adsorption and separation properties and the study of effect of template on the size and performance of the prepared beads are suitable from both economical and research point of view in MIP field.
Citations
More filters
TL;DR: A survey of the literature covering the development of molecular imprinting science and technology over the years 2004–2011 and efforts to apply these polymeric materials to a range of application areas is presented.
Abstract: Herein, we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004-2011. In total, 3779 references to the original papers, rev ...
413 citations
TL;DR: In this review, progresses in applications of enantio-selective recognition by MIPs will be critically reviewed for the recent period since 2007.
82 citations
TL;DR: A novel dummy template molecularly imprinted polymer (DMIP) based on a vinyl-SiO2 microspheres surface for the simultaneous selective recognition and enrichment of 18 amino acids was prepared via a surface molecular imprinting technique using theanine as a dummy template, indicating that the obtained DMIP sorbents have high selectivity.
41 citations
19 Oct 2020
TL;DR: In this article, a critical review of morphology design and control of spherical molecular imprinted polymers (MIPs) is presented, focusing on solid sphere, core-shell, hollow and mesoporous MIPs.
Abstract: Molecularly imprinted polymers (MIPs) display specific recognition ability for their template in shape, size and functional monomers. The morphology has an important influence on the binding capacity of MIPs, thus affecting the enrichment efficiency and detection sensitivity. In this critical review, we highlight the morphology design and control of spherical MIPs, mainly focusing on solid sphere, core–shell, hollow and mesoporous MIPs. The methods for preparation of MIPs of different morphologies are summarized, and typical TEM or SEM images are displayed. The influence of morphology on the application of MIPs is highlighted. Finally, we discuss the remaining challenges, and some significant attempts in further improving the morphology of MIPs are also proposed.
17 citations
References
More filters
TL;DR: In this article, a successful enantioseparation of d, l -phenylalanine (Phe) was achieved for the first time by using d -Phe imprinted P(MAA-co-EGDMA) microbeads as HPLC stationary phase.
47 citations
TL;DR: The preparation and characterization of a PA is reported for the recognition of blistering chemical warfare agent sulphur mustard (SM) for the first time, and the SM imprinted PA exhibited more surface area when compared to the control non-imprinted polymer (NIP).
38 citations
35 citations
TL;DR: In this article, a method to remove template from molecularly imprinted polymer (MIP) and reduce template bleeding using accelerated solvent extraction (ASE) has been developed, and the extraction procedure was completed in 70 min.
24 citations
TL;DR: In this paper, a molecular imprinted polymer (MIP) using caffeine as the template and methacrylic acid (MAA) as the functional monomer was prepared, and linear and quadratic equations for concentration and sorbents to adsorption amounts were expressed, and the advertisersorption equilibrium data were also related into the Freundlich isotherm model.
Abstract: A molecular imprinted polymer (MIP) using caffeine as the template and methacrylic acid (MAA) as the functional monomer was prepared. Acetonitrile was used as the porogen with ethylene glycol dimethacrylate (EGDMA) as the crosslinker and 2,2'-azobis(isobutyronitrile) (AIBN) as the initiator. By a linear and nonlinear regression analysis, the experimental parameters in the equilibrium isotherms were estimated. Then, the linear and quadratic equations for concentration and sorbents to adsorption amounts were expressed, and the adsorption equilibrium data were also cor- related into the Freundlich isotherm model. Comparisons of caffeine adsorption isotherm on C18 particles as well as the molecular imprinted polymer were made. The results showed that the caffeine-imprinted polymer showed extraordi- narily higher adsorption ability than C18 particles.
24 citations