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Open accessJournal ArticleDOI: 10.1002/ADVS.202003627

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

05 Mar 2021-Advanced Science (Wiley)-Vol. 8, Iss: 8, pp 2003627-2003627
Abstract: Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.

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Topics: Self-healing hydrogels (62%)
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28 results found


Journal ArticleDOI: 10.1002/ADFM.202103391
Zhekai Jin1, Lei Yang1, Shun Shi1, Tianyou Wang1  +3 moreInstitutions (3)
Topics: Bioelectronics (77%)

9 Citations


Journal ArticleDOI: 10.1039/D1BM00911G
Xiaodong Jing1, Yanzhen Sun1, Yang Liu1, Xiaoli Ma  +1 moreInstitutions (1)
Abstract: Timely and effective wound treatment is of great significance in acute bleeding caused by accidents and chronic wounds such as diabetic foot ulcers, venous leg ulcers, pressure sores. A hydrogel as wound dressing can provide a suitable microenvironment for wound healing and prevent bacteria and dust from reaching the wound. The loading of therapeutic factors in the hydrogel has been proved to accelerate wound healing. Polydeoxyribonucleotide (PDRN), as a series of nucleic acid fragments extracted from salmon, has the functions of improving angiogenesis, promoting cell activity, increasing collagen synthesis, and developing the anti-inflammatory response. These effects have positive implications for wound healing. But naked PDRN is difficult to take up by cells. Inspired by gene vectors, we prepared a PDRN-loaded CaCO3 nanoparticle (PCNP) to improve the delivery efficiency of PDRN. PCNPs were encapsulated in an alginate/chitosan-based hydrogel (Gel@PCNPs). The prepared hydrogel has plasticity and is suitable for various irregular wounds. The released gene carrier, PCNP, can be effectively taken up by skin fibroblasts. Under the action of PDRN, the wound healing rate has been confirmed to be significantly accelerated. We believe that this polysaccharide-based hydrogel loaded with PDRN vectors is a promising wound dressing.

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Topics: Wound healing (52%)

3 Citations


Journal ArticleDOI: 10.1021/ACS.LANGMUIR.1C01815
Wenlong Xu1, Zhiwen Zhang1, Xin Zhang1, Yuanhan Tang1  +4 moreInstitutions (1)
27 Oct 2021-Langmuir
Abstract: Metal ion-induced peptide assembly is an interesting field. As compared to traditional antibacterial Ag+, rare earth metal ions possess the advantage of antibacterial performance with photostability and low toxicity. Herein, a new peptide Fmoc-FFWDD-OH was designed and synthesized, which could form a stable hydrogel induced by rare earth metal ions, including Tb3+, Eu3+, and La3+. The mechanical properties were characterized by rheological measurements, and they exhibited elasticity-dominating properties. Transmission electron microscopy (TEM) images showed a large number of nanoscale fiber structures formed in the hydrogel. Circular dichroism (CD) spectra, Fourier transform infrared (FT-IR) spectra, ThT assays, and X-ray diffraction (XRD) pattern illustrated the formation mechanism of the fiber structure. The rare earth ion-induced peptide hydrogel was proved to possess good antibacterial performance on Escherichia coli (E. coli) with excellent biocompatibility. The introduction of rare earth metal ions may have some potential applications in the biological antibacterial and medical fields.

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1 Citations


Journal ArticleDOI: 10.1021/ACSAMI.1C10854
Bolun Peng1, Yujie Gao1, Quanqian Lyu1, Zhanjun Xie1  +3 moreInstitutions (1)
Abstract: Solar-driven steam generation has been recognized as a sustainable and low-cost solution to freshwater scarcity using abundant solar energy. To harvest freshwater, various interfacial evaporators with rational designs of photothermal materials and structures have been developed concentrating on increasing the evaporation rate in the past few years. However, pathogenic microorganism accumulation on the evaporators by long-duration contact with natural water resources may lead to the deterioration of water transportation and the reduction of the evaporation rate. Here, we develop cationic photothermal hydrogels (CPHs) based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC) and photothermal polypyrrole (PPy) with bacteria-inhibiting capability for freshwater production via solar-driven steam generation. A rapid water evaporation rate of 1.592 kg m-2 h-1 under simulated solar irradiation is achieved with CPHs floating on the water surface. Furthermore, we find that CPHs possess nearly 100% antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The significant bacteria-inhibiting capability is mainly attributed to the large number of ammonium groups on the CPH network. Moreover, we show that CPHs exhibit good applicability with stable evaporation in natural lake water over 2 weeks, and the number of bacteria in purified lake water is significantly reduced. The device based on CPHs can achieve ∼0.49 kg m-2 h-1 freshwater production from lake water under natural sunlight. This study provides an attractive strategy for the evaporator to inhibit biological contamination and a potential way for long-term stable freshwater production from natural water resources in practical application.

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Topics: Water transport (56%)

1 Citations



References
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58 results found


Journal ArticleDOI: 10.1021/NN800596W
24 Feb 2009-ACS Nano
Abstract: Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity. The toxicity of starch-coated silver nanoparticles was studied using normal human lung fibroblast cells (IMR-90) and human glioblastoma cells (U251). The toxicity was evaluated using changes in cell morphology, cell viability, metabolic activity, and oxidative stress. Ag-np reduced ATP content of the cell caused damage to mitochondria and increased production of reactive oxygen species (ROS) in a dose-dependent manner. DNA damage, as measured by single cell gel electrophoresis (SCGE) and cytokinesis blocked micronucleus assay (CBMN), was also dose-dependent and more prominent in the cancer cells. The nanoparticle treatment caused cell cycle arrest in G2/M phase possibly due to repair of damaged DNA. Annexin-V propidium iodide (PI) staining showed no massive apoptosis or necrosis. The transmission electron microscopic (TEM) analysis indicated the presen...

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Topics: Propidium iodide (58%), Genotoxicity (57%), Silver nanoparticle (56%) ... show more

2,904 Citations


Open accessJournal ArticleDOI: 10.1146/ANNUREV-MATSCI-062910-100429
Abstract: Mussels attach to solid surfaces in the sea. Their adhesion must be rapid, strong, and tough, or else they will be dislodged and dashed to pieces by the next incoming wave. Given the dearth of synthetic adhesives for wet polar surfaces, much effort has been directed to characterizing and mimicking essential features of the adhesive chemistry practiced by mussels. Studies of these organisms have uncovered important adaptive strategies that help to circumvent the high dielectric and solvation properties of water that typically frustrate adhesion. In a chemical vein, the adhesive proteins of mussels are heavily decorated with Dopa, a catecholic functionality. Various synthetic polymers have been functionalized with catechols to provide diverse adhesive, sealant, coating, and anchoring properties, particularly for critical biomedical applications.

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1,175 Citations


Journal ArticleDOI: 10.1016/J.BIOMATERIALS.2017.01.011
Xin Zhao1, Hao Wu1, Baolin Guo1, Ruonan Dong1  +2 moreInstitutions (2)
01 Apr 2017-Biomaterials
Abstract: Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing. These hydrogels presented good self-healing, electroactivity, free radical scavenging capacity, antibacterial activity, adhesiveness, conductivity, swelling ratio, and biocompatibility. Interestingly, the hydrogel with an optimal crosslinker concentration of 1.5 wt% PEGS-FA showed excellent in vivo blood clotting capacity, and it significantly enhanced in vivo wound healing process in a full-thickness skin defect model than quaternized chitosan/PEGS-FA hydrogel and commercial dressing (Tegaderm™ film) by upregulating the gene expression of growth factors including VEGF, EGF and TGF-β and then promoting granulation tissue thickness and collagen deposition. Taken together, the antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.

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853 Citations


Journal ArticleDOI: 10.1016/J.BIOMATERIALS.2018.08.044
Jin Qu1, Xin Zhao1, Yongping Liang1, Tianlong Zhang1  +2 moreInstitutions (2)
01 Nov 2018-Biomaterials
Abstract: Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical significance in healthcare, especially for joints skin wound healing. Here, we designed a kind of self-healing injectable micelle/hydrogel composites with multi-functions as wound dressing for joint skin damage. By combining the dynamic Schiff base and copolymer micelle cross-linking in one system, a series of hydrogels were prepared by mixing quaternized chitosan (QCS) and benzaldehyde-terminated Pluronic®F127 (PF127-CHO) under physiological conditions. The inherent antibacterial property, pH-dependent biodegradation and release behavior were investigated to confirm multi-functions of wound dressing. The hydrogel dressings showed suitable stretchable and compressive property, comparable modulus with human skin, good adhesiveness and fast self-healing ability to bear deformation. The hydrogels exhibited efficient hemostatic performance and biocompatibility. Moreover, the curcumin loaded hydrogel showed good antioxidant ability and pH responsive release profiles. In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model. Taken together, the antibacterial adhesive hydrogels with self-healing and good mechanical property offer significant promise as dressing materials for joints skin wound healing.

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630 Citations


Journal ArticleDOI: 10.1021/ACSNANO.6B05318
Lu Han1, Xiong Lu1, Xiong Lu2, Liu Kezhi1  +10 moreInstitutions (7)
06 Mar 2017-ACS Nano
Abstract: Adhesive hydrogels are attractive biomaterials for various applications, such as electronic skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both adequate adhesiveness and excellent mechanical properties remains a challenge. Inspired by the adhesion mechanism of mussels, we used a two-step process to develop an adhesive and tough polydopamine-clay-polyacrylamide (PDA-clay-PAM) hydrogel. Dopamine was intercalated into clay nanosheets and limitedly oxidized between the layers, resulting in PDA-intercalated clay nanosheets containing free catechol groups. Acrylamide monomers were then added and in situ polymerized to form the hydrogel. Unlike previous single-use adhesive hydrogels, our hydrogel showed repeatable and durable adhesiveness. It adhered directly on human skin without causing an inflammatory response and was easily removed without causing damage. The adhesiveness of this hydrogel was attributed to the presence of enough free catechol groups in the hydrogel, which we...

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Topics: Self-healing hydrogels (63%)

417 Citations