Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
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TLDR
An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.Abstract:
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of the total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects of cellular and circuit function. Here we provide an overview of the current state of the field of interneuron research, focusing largely on the hippocampus. We discuss recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations. We also discuss recent technological advances and approaches that have permitted high-resolution, subtype-specific examination of their roles in numerous neural circuit disorders and the emerging therapeutic strategies to ameliorate such pathophysiological conditions. The ultimate goal of this review is not only to provide a touchstone for the current state of the field, but to help pave the way for future research by highlighting where gaps in our knowledge exist and how a complete appreciation of their roles will aid in future therapeutic strategies.read more
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A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Zizhen Yao,Cindy T. J. van Velthoven,Thuc Nghi Nguyen,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Megan Chiang,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,Nathan W. Gouwens,James Gray,Lucas T. Graybuck,Michael Hawrylycz,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Changkyu Lee,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +38 more
TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.
Posted ContentDOI
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Zizhen Yao,Thuc Nghi Nguyen,Cindy T. J. van Velthoven,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,James Gray,Lucas T. Graybuck,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +34 more
TL;DR: This study establishes a molecular architecture of the mammalian isocortex and hippocampal formation for the first time, and begins to shed light on its underlying relationship with the development, evolution, connectivity and function of these two brain structures.
Journal ArticleDOI
Robust decomposition of cell type mixtures in spatial transcriptomics
Dylan M. Cable,Dylan M. Cable,Dylan M. Cable,Evan Murray,Luli S. Zou,Luli S. Zou,Aleksandrina Goeva,Evan Z. Macosko,Evan Z. Macosko,Fei Chen,Fei Chen,Rafael A. Irizarry +11 more
TL;DR: In this paper, the authors propose robust cell type decomposition (RCTD) to detect mixtures and identify cell types on simulated datasets, which can accurately reproduce known cell type and subtype localization patterns in Slide-seq and Visium datasets.
Posted ContentDOI
Robust decomposition of cell type mixtures in spatial transcriptomics
Dylan M. Cable,Dylan M. Cable,Evan Murray,Luli S. Zou,Luli S. Zou,Aleksandrina Goeva,Evan Z. Macosko,Evan Z. Macosko,Fei Chen,Rafael A. Irizarry +9 more
TL;DR: Robust Cell Type Decomposition (RCTD) is developed, a computational method that leverages cell type profiles learned from single-cell RNA sequencing data to decompose mixtures, such as those observed in spatial transcriptomic technologies.
Journal ArticleDOI
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.
Kenneth D. Harris,Hannah Hochgerner,Nathan G. Skene,Nathan G. Skene,Lorenza Magno,Linda Katona,Carolina Bengtsson Gonzales,Peter Somogyi,Nicoletta Kessaris,Sten Linnarsson,Jens Hjerling-Leffler +10 more
TL;DR: The results elucidate the complexity of inhibitory neurons in one of the simplest cortical structures and show that characterizing these cells requires continuous modes of variation as well as discrete cell classes.
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