Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming.
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Cites background from "Histamine receptor agonist alleviat..."
...This study showed that an H3R agonist (immethridine) had a preventive efficacy toward chronic heart and kidney diseases (Noguchi et al., 2020)....
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...More recently, an interesting study showed that histamine plays an anti-inflammatory role by suppressing inflammatory cytokine gene expression through the histamine H3 receptor (H3R) in cardiorenal syndrome animal model (Figure 4) (Noguchi et al., 2020)....
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References
2,435 citations
"Histamine receptor agonist alleviat..." refers methods in this paper
...Gene ontology (GO) enrichment analysis in biological processes and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway using the ToppGene Suite (20) analyses of these differentially expressed 150 transcripts revealed gene sets with significantly down-regulated responses to proinflammatory signals in the Imm-treated ANS group versus the ANS group....
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1,912 citations
"Histamine receptor agonist alleviat..." refers background in this paper
...In recent years, many investigators have become interested in this relationship with respect to cardiorenal syndrome and in the role that chronic kidney disease plays in being a strong risk factor for heart failure (2, 3)....
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"Histamine receptor agonist alleviat..." refers background in this paper
...Regarding the association of histamine with renal injury, it has been previously demonstrated that a bolus injection of the platelet activating factor causes histological damages in the proximal tubule and significant histamine release in isolated perfused rat kidneys (30)....
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565 citations
"Histamine receptor agonist alleviat..." refers background in this paper
...Specifically, Ang II is a vasoconstrictive hormone in RAS that plays an essential role in the regulation of blood pressure, electrolyte, and volume homeostasis (6)....
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