Journal ArticleDOI
Histologic classification of liver-cell carcinoma in infancy and childhood and its clinical evaluation. A study of 70 cases collected in Japan.
Morio Kasai,Itaru Watanabe +1 more
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The study confirmed the existence of a distinct correlation beween the histologic type of the tumor, its gross appearance, and the clinical course of the disease, as compared with other types of hepatoblastoma.Abstract:
Clinical data and morphological materials from 70 cases of liver-cell carcinoma in infants and children in Japan were collected and studied. The cases were classified into 4 types according to the histopathologic appearance of the epithelial components: 1. adult type; 2. anaplastic type; 3. embryonal type; and 4. fetal type. The study confirmed the existence of a distinct correlation beween the histologic type of the tumor, its gross appearance, and the clinical course of the disease. Twenty-seven of the 70 cases underwent radical surgery. Postoperative prognosis was studied in these cases according to histologic types of tumor. Of 9 long-term survivors (i.e., surviving more than 2 years), 7 were found to belong to the fetal type. No difference was found in prognosis between the cases with and without osteoid tissue in tumor. The benign character of the fetal type, as compared with other types of hepatoblastoma, was demonstrated even in infants under 12 months of age.read more
Citations
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Journal ArticleDOI
Primary hepatic tumors of childhood.
TL;DR: A clinicopathologic review of 73 cases of primary liver tumors at Texas Children's Hospital, Houston, and Children's Medical Center, Dallas, has documented important prognostic and therapeutic implications for the histologic classification of hepatoblastoma.
Journal ArticleDOI
Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium
Dolores Lopez-Terrada,Rita Alaggio,Maria T. De Dávila,Piotr Czauderna,Eiso Hiyama,Howard M. Katzenstein,Ivo Leuschner,Marcio H. Malogolowkin,Rebecka L. Meyers,Sarangarajan Ranganathan,Yukichi Tanaka,Gail E. Tomlinson,Monique Fabre,Arthur Zimmermann,Milton J. Finegold +14 more
TL;DR: This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology and work towards an International Pediatric Liver Tumors Consensus Classification.
Journal ArticleDOI
Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy
Piotr Czauderna,Dolores Lopez-Terrada,Eiso Hiyama,Beate Häberle,Marcio H. Malogolowkin,Rebecka L. Meyers +5 more
TL;DR: International collaborative efforts in hepatoblastoma have led to a new international histopathologic consensus classification, refinements in risk stratification, advances in chemotherapy, and a better understanding of surgical resection options forming the foundation for the development of an upcoming international therapeutic trial.
Journal ArticleDOI
Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma.
Joel E. Haas,Kimberly A. Muczynski,Mark Krailo,Arthur R. Ablin,Vita J. Land,Teresa J. Vietti,G. Denman Hammond +6 more
TL;DR: It is concluded that features consistent with differentiation in HB convey improved prognosis for survival, and these observations may be important in designing future therapy for children with hepatic tumors.
Journal ArticleDOI
Liver Cancer Stem Cells
Stewart Sell,Hyam L. Leffert +1 more
TL;DR: Analysis of the cells in HCC supports the presence of cells with stem-cell properties (ie, immortality, transplantability, and resistance to therapy), however, definitive markers for these putative cancer stem cells have not yet been found and a liver cancer stem cell has not been isolated.
References
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Book ChapterDOI
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Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood
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