Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index
Christoph Weiler,Mercedes Lopez-Ramos,H. Michael Mayer,Andreas Korge,Christoph J. Siepe,Karin Wuertz,Véronique Weiler,Norbert Boos,Andreas G. Nerlich +8 more
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TLDR
This study demonstrated that histological disc alterations in surgical specimens can be graded in a reliable manner based on a quantitative histologic degeneration score (HDS), and increased BMI was identified as a positive risk factor for the development of symptomatic, clinically significant disc degeneration.Abstract:
Although histopathological grading systems for disc degeneration are frequently used in research, they are not yet integrated into daily care routine pathology of surgical samples. Therefore, data on histopathological changes in surgically excised disc material and their correlation to clinical parameters such as age, gender or body mass index (BMI) is limited to date. The current study was designed to correlate major physico-clinical parameters from a population of orthopaedic spine center patients (gender, age and BMI) with a quantitative histologic degeneration score (HDS). Excised lumbar disc material from 854 patients (529 men/325 women/mean age 56 (15-96) yrs.) was graded based on a previously validated histologic degeneration score (HDS) in a cohort of surgical disc samples that had been obtained for the treatment of either disc herniation or discogenic back pain. Cases with obvious inflammation, tumor formation or congenital disc pathology were excluded. The degree of histological changes was correlated with sex, age and BMI. The HDS (0-15 points) showed significantly higher values in the nucleus pulposus (NP) than in the annulus fibrosus (AF) (Mean: NP 11.45/AF 7.87), with a significantly higher frequency of histomorphological alterations in men in comparison to women. Furthermore, the HDS revealed a positive significant correlation between the BMI and the extent of histological changes. No statistical age relation of the degenerative lesions was seen. This study demonstrated that histological disc alterations in surgical specimens can be graded in a reliable manner based on a quantitative histologic degeneration score (HDS). Increased BMI was identified as a positive risk factor for the development of symptomatic, clinically significant disc degeneration.read more
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Lumbar Disc Degenerative Disease: Disc Degeneration Symptoms and Magnetic Resonance Image Findings
Shafaq Saleem,Hafiz Muhammad Aslam,Muhammad Asim Khan Rehmani,Aisha Raees,Arsalan Ahmad Alvi,Junaid Ashraf +5 more
TL;DR: The frequent occurrence of lumbar disc degenerative disease in advance age is reported and research efforts should endeavor to reduce risk factors and improve the quality of life.
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Association of Abdominal Obesity with Lumbar Disc Degeneration – A Magnetic Resonance Imaging Study
Jani Takatalo,Jaro Karppinen,Jaro Karppinen,Jaro Karppinen,Simo Taimela,Jaakko Niinimäki,Jaana Laitinen,Roberto Blanco Sequeiros,Dino Samartzis,Raija Korpelainen,Raija Korpelainen,Simo Näyhä,Jouko Remes,Osmo Tervonen +13 more
TL;DR: Measures of abdominal obesity in MRI and waist circumference were associated with disc degeneration among 21-year-old males, but not among females.
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Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue.
TL;DR: It is concluded that, in degenerated and herniated discs, blood vessels and nerves are confined to proteoglycan‐depleted regions of disrupted tissue, especially within annulus fissures.
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The epidemiology and pathophysiology of lumbar disc herniations
TL;DR: Patients with a family history of disc disease or who are in physically demanding jobs, or who have certain medical comorbidities such as obesity, are at an increased risk of developing a lumbar disc herniation.
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Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model
Georg Omlor,Andreas G. Nerlich,H. Lorenz,Thomas Bruckner,Wiltrud Richter,Michael Pfeiffer,T. Gühring +6 more
TL;DR: Although nucleotomy and administration of the implant material did not cause generalized inflammation of the disc, localized annular damage with annulus inflammation and scarring resulted in detrimental degenerative disc changes, so therapeutic strategies should strongly focus on the prevention of annularDamage or techniques for annular repair to remain disc integrity.
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