Histone recognition and large-scale structural analysis of the human bromodomain family.
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...…associate with nucleosomal DNA, preceding and commonly also enabling occupancy of other TFs via repositioning nucleosomes, recruiting chromatin modifiers, or protecting enhancer regions from DNA methylation (Ghisletti et al., 2010; Sérandour et al., 2011; Zaret and Carroll, 2011) (Figure 2B)....
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...…years, binding of p300 or CBP, two highly homologous HATs, has been used for genome-wide enhancer mapping in different cell types and tissues (Ghisletti et al., 2010; Heintzman et al., 2009; Kim et al., 2010; Rada-Iglesias et al., 2011; Visel et al., 2009). p300/CBP are ubiquitously…...
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...Importantly, although the protein family database Pfam (Finn et al., 2010) extended the BRD fold from the initially predicted central helices aA and aB (Haynes et al....
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