Journal ArticleDOI
History of the Discovery and Development of Biomodulina T (InmunyVital®), a Useful Immunomodulator with a Broad Range of Clinical Applications
Rodriguez Martin,Roman R +1 more
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TLDR
Clinical trials and first and recent reports of new scientific advances show that Biomodulina T (InmunyVital®) is a modulator of immune responses and inflammation that is very useful for restoring the immune system in young and elderly people with allergies, asthma, immunodeficiency, autoimmune diseases, and infectious diseases.Abstract:
Biomodulina T, the active ingredient in InmunyVital®, is a polypeptide thymic factor that modulates immune responses and inflammation. Biomodulina T stimulates the differentiation, maturation and proliferation of CD3 T cell populations and CD4 and CD8 T cell subpopulations. Additionally, Biomodulina T improves the ability of T cells to produce cytokines, therefore enhancing T lymphocyte function. Additionally, Biomodulina T stimulates the thymus gland and, thus, promotes the recovery of normal thymus mass and size in children with thymic hypoplasia and restores the functions of immunosenescent T cells in aging people.
The thymus gland slowly shrinks with age, and the levels of the thymic factors it produces decrease in the blood. Moreover, thymus-dependent immunity, including T cell immunity and thymus- dependent antibody production, decreases with thymus size in adult people. For that reason, older adults are generally at a higher risk of becoming severely ill from infectious diseases, such as influenza, COVID-19 and other diseases. As people age, “immunosenescence” occurs; immunosenescence means that with age, the ability to produce vigorous responses to infections gradually diminishes compared to that observed at younger ages during which the thymus gland, thymic factor levels, and immune responses are healthy and strong. In addition, in older adults, low-grade, chronic systemic inflammation, called “inflamm-aging”, occurs, and this phenomenon increases susceptibility to age-related inflammatory diseases.
In 1984, with the aim of developing biological response modifiers, I established the laboratory of Biomodulators in Havana, where I created and developed the immunomodulatory thymic factor that I called “Biomodulina T”. The biological activity of Biomodulina T was demonstrated in several in vitro and in vivo studies in our laboratory and in independent laboratories. An extensive series of preclinical toxicological studies were conducted in different species, such as mice, rats, guinea pigs, rabbits and dogs. All these studies demonstrated that Biomodulina T is an active and safe thymic factor.
We conducted clinical trials with Biomodulina T in patients with multiple sclerosis, chronic hepatitis B, rheumatoid arthritis, Crohn's disease, Behcet's syndrome, and selective deficiency of IgA as well as in geriatric populations. In 1994, I obtained the sanitary registration of Biomodulina T as an immunomodulatory drug.
Since that time, we conducted other clinical trials in children with repeated infections and primary immunodeficiencies and in adults with systemic lupus erythematosus, uveitis, myasthenia gravis, chronic obstructive pulmonary disease (COPD), and respiratory infections.
This article identifies the milestones involved in the creation and development of Biomodulina T. Since its discovery 35 years ago, the first and recent reports of new scientific advances show that Biomodulina T (InmunyVital®) is a modulator of immune responses and inflammation that is very useful for restoring the immune system in young and elderly people with allergies, asthma, immunodeficiency, autoimmune diseases, and infectious diseases. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in the context of cancer and vaccines, for reversing immunosenescence and for improving the healthspan in general aging.read more
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Effect of Biomodulina-T® and VA-MENGOC-BC® on lymphocyte subpopulations in older adults.
Elizabeth Hernández Ramos,Vianed Marsán Suárez,Imilla Casado Hernández,R. Gómez,Dagmar García Rivera,Mary Carmen Reyes Zamora,Arturo Chang Monteagudo,Yenisey Triana Marrero,Gabriela Díaz Domínguez,Yaneisy Duarte Pérez,Consuelo Macías Abraham,Ana María Simón Pita +11 more
TL;DR: The combination of the VA-MENGOC-BC® (V-BC) vaccine and the Biomodulina T® (BT) drug could immunomodulate both the innate and adaptive branches of the immune system simultaneously.
Síntesis intratecal de IgG y permeabilidad de la barrera sangre-LCR en el seguimiento de pacientes con esclerosis múltiple tratados con biomodulina T
Journal ArticleDOI
History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications
TL;DR: Biomodulina T (InmunyVital®) as mentioned in this paper is a thymic factor that modulates immune response and inflammation that stimulates the differentiation, maturation and proliferation of T cells.
References
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Journal ArticleDOI
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
Journal ArticleDOI
COVID-19 infection: the perspectives on immune responses.
Yufang Shi,Ying Wang,Changshun Shao,Jianan Huang,Jianhe Gan,Xiaoping Huang,Enrico M. Bucci,Mauro Piacentini,Giuseppe Ippolito,Gerry Melino +9 more
TL;DR: The role of asymptomatic SARS-CoV-2 infected individuals in disseminating the infection remains to be defined and the conventional wisdom based on overall immunity of the infected patients cannot explain this broad spectrum in disease presentation.
Journal ArticleDOI
Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients.
Hong-Yi Zheng,Mi Zhang,Cui-Xian Yang,Nian Zhang,Xicheng Wang,Xinping Yang,Xingqi Dong,Yong-Tang Zheng +7 more
TL;DR: Data indicate that COVID-19, similar to some chronic infections, damages the function of CD4- T cells and promotes excessive activation and possibly subsequent exhaustion of CD8+ T cells, and perturbations of T cell subsets may eventually diminish host antiviral immunity.