HIV Treatment as Prevention: Optimising the Impact of Expanded HIV Treatment Programmes
Citations
124 citations
Cites background from "HIV Treatment as Prevention: Optimi..."
...To date, this is the first study to systematically review and quantify the ART cascade among FSWs globally, which builds on a limited review already undertaken by the authors [15]....
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...transmitting HIV [15,17], it is crucial to understand the extent to which FSWs currently access ART, and continue ART with good adherence....
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...Ensuring high levels of ART uptake, adherence and retention among FSWs, would provide not only individual benefits to HIV-infected FSWs, but could also help reduce HIV transmission at the population level [15,16]....
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100 citations
Cites background from "HIV Treatment as Prevention: Optimi..."
...At the same time, the “Universal Access” agenda has made equity a guiding principle for national programmes, leading to greater prioritisation of key populations, including sex workers [10,11]....
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83 citations
83 citations
Cites background from "HIV Treatment as Prevention: Optimi..."
...[19], or prioritised for treatment as prevention [20])....
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78 citations
References
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"HIV Treatment as Prevention: Optimi..." refers background or methods in this paper
...The HPTN 052 study [4] demonstrated that earlier ART initiation can reduce heterosexual HIV transmission [5]....
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...Observational and clinical trial data that link transmission events confirm that heterosexual transmissions occur from asymptomatically infected individuals with CD4 counts between 350 and 500 cells/ml [5,11], and the HPTN 052 study demonstrated a 96% reduction in transmission associated with treatment initiation at a CD4 cell count between 350 and 550 cells/ml compared to delaying treatment until CD4 count was below 250 cells/ml [5]....
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...was associated with a 41% increased hazard of adverse clinical outcome [5]....
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...Trial and observational data have demonstrated the efficacy of ART in preventing HIV transmission in stable serodiscordant heterosexual partnerships [5,11], and recent WHO guidelines for stable serodiscordant couples already include offering ART to the HIV-infected partner irrespective of CD4 cell count, in addition to behaviour change counselling [69]....
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...7 per 100 person-years at risk ([5]; among those with CD4 counts of 350–500 cells/ml: [11])....
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