HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
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...Endotoxin (lipopolysaccharide), produced by all gram-negative bacteria, activates macrophages to release cytokines that are potentially letha...
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...TNF amplifies and prolongs the inflammatory response by activating other cells to release both cytokines such as interleukin 1 (IL-1) and high mobility group B1 (HMGB1), and mediators such as eicosanoids, nitric oxide and reactive oxygen species, which promote further inflammation and tissue injur...
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Cites background from "HMG-1 as a Late Mediator of Endotox..."
...gif" NDATA ITEM> ]> Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel diseas...
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References
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