HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
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...For example, in mouse models of glioma, it has been shown that both temozolomide and radiation treatment cause the release of HMGB1 from dying cancer cells into the microenvironment, where it signals via TLR2 on DCs to enhance anti-tumor immunity (Curtin et al., 2009)....
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"HMGB1 Mediates Endogenous TLR2 Acti..." refers background in this paper
...Therefore, our data suggest that the vast majority of CD11cþ-infiltrating immune cells in Ad-Flt3L and Ad-TKtreated brain tumors are bone marrow-derived mDC. TLR2 Expression on BMDC Is Necessary for Tumor Regression To determine if TLRs were involved in mediating the efficacy of the combined antiglioma treatment, we investigated whether Myd88 knockout mice would respond to our therapy, as Myd88 is required for downstream signaling from every TLR except TLR3 [12,50]....
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...To determine if TLRs were involved in mediating the efficacy of the combined antiglioma treatment, we investigated whether Myd88 knockout mice would respond to our therapy, as Myd88 is required for downstream signaling from every TLR except TLR3 [12,50]....
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...TLR signaling induces production of pro-inflammatory cytokines and upregulation of costimulatory molecules, which result in the activation of the adaptive immune system [12]....
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4,108 citations
"HMGB1 Mediates Endogenous TLR2 Acti..." refers background in this paper
...While TLRs play an important role in detecting and regulating the innate immune response to bacteria, viruses, and/or parasites, TLRs are also necessary for the induction of an adaptive immune response through the activation and maturation of DCs and macrophages [20,21]....
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4,082 citations
"HMGB1 Mediates Endogenous TLR2 Acti..." refers background in this paper
...[55], soluble CD14 [29,70], and possibly larger hydrophobic molecular complexes (Hyppo's) [71]....
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3,852 citations
"HMGB1 Mediates Endogenous TLR2 Acti..." refers methods in this paper
...BMDC were generated as described previously [38] with modifications....
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