HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity.
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Cites background from "HNSCC cell lines positive for HPV a..."
...As a result of the impaired activation of non-homologous end joining and homologous recombination DNA repair mechanisms, HPV-positive cells fail to resolve radiation-induced double strand breaks, increasing their intrinsic radiosensitivity [92, 93]....
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Cites background from "HNSCC cell lines positive for HPV a..."
...Underlying reasons for the higher radiosensitivity of HPV positive HNSCC may be an impaired DNA repair capacity in HPV positive tumor cells [100] and/or higher immunogenic effects of HPV positive tumors [101]....
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"HNSCC cell lines positive for HPV a..." refers background in this paper
...In HPV-neg ative strains we additional ly validated the absence of or HPV and p16 possess higher cellula r radi osensitivity due to an imp aired c.2013.03 .013 the main viral oncogenes E6 and E7 of HPV-16 (not shown), whereas in HPV-pos itive strains we confirmed active transcriptio n of E6 and E7 (Fig....
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...Notably, from the four HPV-16-positive cell lines only 93- VU-147T carries a mutation in p53 and only this strain lacks the high level of residual DSBs after irradiation (Fig....
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...Sequencing of the respective PCR products revealed that the strains 93-VU147T, UD-SCC-2, UM-SCC- 47 and UPCI-SCC- 154 contain sequence s of the most abundant high-risk type HPV-16, while UT-SCC-45 cells contain sequence s of a different high-risk type, HPV-33....
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...In recent years, it has become apparent that a distinct HNSCC entity exists which is depende nt on infection with high-risk types of human papillomavir us (HPV), especially HPV type 16 (HPV-16) [1]....
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...In HPV-negativ e strains the absence of the viral oncogenes E6 and E7 of the most abundan t high-risk type HPV-16 was additionally verified by genomic PCR....
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"HNSCC cell lines positive for HPV a..." refers background in this paper
...Besides a number of other functions, E6 degrades p53 and E7 inactivates members of the retinobla stoma (Rb) protein family (RB, p107, p130), thereby liberating transcriptio n factor E2F from Rb-mediated inhibition [3]....
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