Holding the inflammatory system in check: NLRs keep it cool.
Citations
63 citations
Cites background from "Holding the inflammatory system in ..."
...The importance of NLRs in regulating inflammation is highlighted by their evolutionary conservation across vertebrate species and the association of genetic mutations in several NLR genes with autoinflammatory diseases (9)....
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34 citations
Cites background from "Holding the inflammatory system in ..."
...NLRP4 expression regulates type-1 interferon signaling and NF-kB activity induced by intracellular adapter proteins and kinases that functionally connect TNF and IL-1R receptors to NF-kB responses [105]....
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...NOD2 expression results in activation of the MAPK and NFkB inflammatory pathways and a reduction in toll-like receptor mediated inflammatory responses [105]....
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...Inflammasomes are multimeric protein complexes that serve as platforms for activation of the innate immune response through mediation of the NFkB and interferon signaling pathways [105,106]....
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23 citations
Cites background from "Holding the inflammatory system in ..."
...Mitochondria play vital roles in the energy metabolism of cells, reactive oxygen species (ROS) generation, programmed cell death, autophagy and innate antiviral responses [20]....
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18 citations
17 citations
Cites background from "Holding the inflammatory system in ..."
...The host inflammatory response is a double-edged sword in infection (Jha and Pan-Yun, 2015)....
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References
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"Holding the inflammatory system in ..." refers background in this paper
...Also, mutations in NOD2 are associated with susceptibility to Crohn’s disease (an inflammatory bowel disease) and Blau syndrome (a granulomatous inflammatory disease) [9,10]....
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4,838 citations
"Holding the inflammatory system in ..." refers background in this paper
...Also, mutations in NOD2 are associated with susceptibility to Crohn’s disease (an inflammatory bowel disease) and Blau syndrome (a granulomatous inflammatory disease) [9,10]....
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