Journal ArticleDOI
Hollow microneedles: A perspective in biomedical applications.
Álvaro Cárcamo-Martínez,Brónach Mallon,Juan Domínguez-Robles,Lalitkumar K. Vora,Qonita Kurnia Anjani,Ryan F. Donnelly +5 more
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TLDR
In this article, a review on hollow microneedles, materials and methods for their fabrication as well as their application in drug delivery, vaccine delivery and monitoring purposes is presented.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2021-03-04. It has received 75 citations till now. The article focuses on the topics: Drug delivery & Transdermal.read more
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Journal ArticleDOI
Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants
Ke Peng,Lalitkumar K. Vora,Juan Domínguez-Robles,Yara A. Naser,Mingshan Li,Eneko Larrañeta,Ryan F. Donnelly +6 more
TL;DR: In this article, a hybrid microneedle patch with implantable poly(lactic-co-glycolic acid) (PLGA) tips aligned with hydrogel-forming micronedle bases (HFMB) using a dissolvable material was introduced.
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Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections.
Ke Peng,Lalitkumar K. Vora,Ismaiel Tekko,Andi Dian Permana,Juan Domínguez-Robles,Delly Ramadon,Philip Chambers,Helen O. McCarthy,Eneko Larrañeta,Ryan F. Donnelly +9 more
TL;DR: In this article, microneedle patches (DMP) were loaded with micronized particles of AmB to achieve localised and long-acting intradermal delivery of Amb for treatment of cutaneous fungal infections.
Journal ArticleDOI
Dissolving microneedles: Applications and growing therapeutic potential.
TL;DR: The potential applications of dissolving microneedles as a drug delivery system in different therapeutic areas in both research literature and clinical trials is highlighted in this paper , including the delivery of cosmetics, vaccine delivery, diagnosis and monitoring, cancer, pain and inflammation, diabetes, hair and scalp disorders and inflammatory skin diseases.
Journal ArticleDOI
Long-acting nanoparticle-loaded bilayer microneedles for protein delivery to the posterior segment of the eye
Yu Wu,Lalitkumar K. Vora,Yujing Wang,Muhammad Faris Adrianto,Ismaiel Tekko,David Waite,Ryan F. Donnelly,Raghu Raj Singh Thakur +7 more
TL;DR: In this article, a model protein, ovalbumin (OVA)-encapsulated PLGA NPs were prepared and optimized using a water-in-oil-inwater (W/O/W) double emulsion method.
Journal ArticleDOI
Nanomaterials for photothermal and photodynamic cancer therapy
Behzad Nasseri,Effat Alizadeh,Farhad Bani,Soodabeh Davaran,Abolfazl Akbarzadeh,Navid Rabiee,Ali Bahadori,Mojtaba Ziaei,Mojtaba Bagherzadeh,Mohammad Reza Saeb,Masoud Mozafari,Michael R. Hamblin +11 more
TL;DR: The present review focuses on the therapeutic potency of PDT, PTT, and also their combined modalities, which are known alternative protocols with minimal morbidity integrated into gold standard treatments such as surgery, chemotherapy, and radiation therapy at tumor treatment and cancer-related infectious diseases.
References
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Journal ArticleDOI
The skin: an indispensable barrier
TL;DR: Changes in epidermal differentiation and lipid composition lead to a disturbed skin barrier, which allows the entry of environmental allergens, immunological reaction and inflammation in atopic dermatitis.
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Novel mechanisms and devices to enable successful transdermal drug delivery.
TL;DR: This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.
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Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
Devin V. McAllister,Ping M. Wang,Shawn P. Davis,Jung-Hwan Park,Paul J. Canatella,Mark G. Allen,Mark R. Prausnitz +6 more
TL;DR: Microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 μm allowed flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats.
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Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force.
TL;DR: The ability to predict insertion and fracture forces is provided, which facilitates rational design of microneedles with robust mechanical properties.
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Microneedles: A smart approach and increasing potential for transdermal drug delivery system.
Tejashree Waghule,Gautam Singhvi,Sunil Kumar Dubey,Murali Monohar Pandey,Gaurav Gupta,Mahaveer Singh,Kamal Dua +6 more
TL;DR: A new form of delivery system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various problems associated with the conventional formulations.