Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study
Weiva Sieh,Martin Köbel,Teri A. Longacre,David D.L. Bowtell,David D.L. Bowtell,Anna deFazio,Marc T. Goodman,Estrid Høgdall,Suha Deen,Nicolas Wentzensen,Kirsten B. Moysich,James D. Brenton,James D. Brenton,Blaise Clarke,Usha Menon,C. Blake Gilks,Andre E. Kim,Jason Madore,Sian Fereday,Joshy George,Laura Galletta,Galina Lurie,Lynne R. Wilkens,Michael E. Carney,Pamela J. Thompson,Rayna K. Matsuno,Susanne K. Kjaer,Allan Jensen,Claus Høgdall,Kimberly R. Kalli,Brooke L. Fridley,Gary L. Keeney,Robert A. Vierkant,Julie M. Cunningham,Louise A. Brinton,Hannah P. Yang,Mark E. Sherman,Montserrat Garcia-Closas,Jolanta Lissowska,Kunle Odunsi,Carl Morrison,Shashikant Lele,Wiam Bshara,Lara Sucheston,Mercedes Jimenez-Linan,Mercedes Jimenez-Linan,Kristy Driver,Jennifer Alsop,Marie Mack,Valerie McGuire,Joseph H. Rothstein,Barry P. Rosen,Marcus Q. Bernardini,Helen Mackay,Amit M. Oza,Eva Wozniak,Elizabeth Benjamin,Aleksandra Gentry-Maharaj,Simon A. Gayther,Anna V. Tinker,Leah M Prentice,Christine Chow,Michael S. Anglesio,Sharon E. Johnatty,Georgia Chenevix-Trench,Alice S. Whittemore,Paul D.P. Pharoah,Ellen L. Goode,David G. Huntsman,David G. Huntsman,Susan J. Ramus +70 more
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TLDR
Clinical trials, stratified by subtype and biomarker status, are needed to establish whether hormone-receptor status predicts response to endocrine treatment, and whether it could guide personalised treatment for ovarian cancer.Abstract:
Summary Background Few biomarkers of ovarian cancer prognosis have been established, partly because subtype-specific associations might be obscured in studies combining all histopathological subtypes. We examined whether tumour expression of the progesterone receptor (PR) and oestrogen receptor (ER) was associated with subtype-specific survival. Methods 12 studies participating in the Ovarian Tumor Tissue Analysis consortium contributed tissue microarray sections and clinical data to our study. Participants included in our analysis had been diagnosed with invasive serous, mucinous, endometrioid, or clear-cell carcinomas of the ovary. For a patient to be eligible, tissue microarrays, clinical follow-up data, age at diagnosis, and tumour grade and stage had to be available. Clinical data were obtained from medical records, cancer registries, death certificates, pathology reports, and review of histological slides. PR and ER statuses were assessed by central immunohistochemistry analysis done by masked pathologists. PR and ER staining was defined as negative ( Findings 2933 women with invasive epithelial ovarian cancer were included: 1742 with high-grade serous carcinoma, 110 with low-grade serous carcinoma, 207 with mucinous carcinoma, 484 with endometrioid carcinoma, and 390 with clear-cell carcinoma. PR expression was associated with improved disease-specific survival in endometrioid carcinoma (log-rank p Interpretation PR and ER are prognostic biomarkers for endometrioid and high-grade serous ovarian cancers. Clinical trials, stratified by subtype and biomarker status, are needed to establish whether hormone-receptor status predicts response to endocrine treatment, and whether it could guide personalised treatment for ovarian cancer. Funding Carraresi Foundation and others.read more
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Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment.
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ARID1A mutations in endometriosis-associated ovarian carcinomas.
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