Journal ArticleDOI
How ageing processes influence cancer.
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In the emerging age of cancer, how can the growing understanding of the biology of ageing inform cancer biology?Abstract:
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of the biology of ageing inform cancer biology?read more
Citations
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Senescence and aging: Causes, consequences, and therapeutic avenues
TL;DR: The role ofsenescence in age-related diseases and how targeting senescence may improve health span and extend life span are reviewed.
Journal ArticleDOI
Heterochromatin: Guardian of the Genome
TL;DR: It is proposed that more comprehensive analyses of heterochromatin roles in tumorigenesis will be integral to future innovations in cancer treatment and the importance of its maintenance for genome integrity is discussed.
Journal ArticleDOI
Insights into the evolution of longevity from the bowhead whale genome
Michael Keane,Jeremy Semeiks,Andrew E. Webb,Yang I. Li,Víctor Quesada,Thomas Craig,Lone Bruhn Madsen,Sipko van Dam,David Brawand,Patrícia Isabel Marques,Pawel Michalak,Lin Kang,Jong Bhak,Hyung-Soon Yim,Nick V. Grishin,Nynne H. Nielsen,Mads Peter Heide-Jørgensen,Elias M. Oziolor,Cole W. Matson,George M. Church,Gary W. Stuart,John C. Patton,J. Craig George,Robert Suydam,Knud Larsen,Carlos López-Otín,Mary J. O'Connell,John W. Bickham,John W. Bickham,Bo Thomsen,João Pedro de Magalhães +30 more
TL;DR: The sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging and finds potentially relevant changes in genes related to additional processes.
Journal ArticleDOI
Stress, cell senescence and organismal ageing.
TL;DR: The role of telomere dysfunction and senescence during the ageing process as well as potential interventions, including pharmacological approaches like telomerase activators and senolytics, to counteract their detrimental effects in ageing and disease are focused on.
References
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Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
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Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years
J. V. G. A. Durnin,J. Womersley +1 more
TL;DR: Skinfold thicknesses at four sites – biceps, triceps, subscapular and supra-iliac – and total body density were measured on 209 males and 272 females aged from 16 to 72 years, finding it necessary to use the logarithm of skinfold measurements in order to achieve a linear relationship with body density.
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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
Journal ArticleDOI
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison,Randy Strong,Zelton D Sharp,James F. Nelson,Clinton M. Astle,Kevin Flurkey,Nancy L. Nadon,J. Erby Wilkinson,Krystyna Frenkel,Christy S. Carter,Christy S. Carter,Marco Pahor,Marco Pahor,Martin A. Javors,Elizabeth Fernandez,Richard A. Miller +15 more
TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.