How do lncRNAs regulate transcription
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...Other lncRNAs can regulate transcription, controlling DNA methyltransferases recruitment, TFs, zinc-finger proteins, and others transcription regulators [1]....
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...Long non-coding RNAs are found within the nucleus, nucleolus, cytoplasm, and even in the mitochondria [38,39], and its localization is a good indicator of their mode of action [1], as shown in Figure 2....
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...The discrepancy of about 20,000 protein-coding genes and over 100,000 different transcripts identified in mammalian transcriptomes highlights the possibility of discovering a novel class of non-translated RNAs [1], beyond those already identified in the 1970s, as part of the translation machinery: ribosomal RNAs (rRNAs) [2] and transfer RNAs (tRNAs) [3]....
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...The most recent NONCODE database source points to over 100,000 lncRNAs in the human genome, but this number seems to be underestimated [1,30,31]....
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"How do lncRNAs regulate transcripti..." refers background in this paper
...Inserting multiple polyadenylation sequences downstream from a lncRNA promoter and interfering with lncRNA transcription using CRISPR interference (159) are more surgically incisive, but negative results must be interpreted with caution because these techniques truncate rather than eliminate lncRNA transcription....
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"How do lncRNAs regulate transcripti..." refers background in this paper
...(3) Indirectly, through the act of transcription Transcription of a lncRNA may regulate the transcription of nearby mRNAgenes, either positively (maintaining active chromatin structure) or negatively (for example, colliding polymerases)....
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...Some lncRNAs may function at the RNA level, for example, as ribozymes or riboswitches (3)....
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