How Dopamine Influences Survival and Cellular Immune Response of Rhipicephalus microplus Inoculated with Metarhizium anisopliae
Thaís A. Corrêa,Jéssica Fiorotti,Emily Mesquita,Laura Nóbrega Meirelles,Mariana Guedes Camargo,Caio Junior Balduino Coutinho-Rodrigues,Allan Felipe Marciano,Vânia Rita Elias Pinheiro Bittencourt,Patrícia Silva Gôlo +8 more
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TLDR
In this article, the effect of DA on the cellular immune response and survival of Rhipicephalus microplus inoculated with M. anisopliae blastospores was evaluated.Abstract:
Dopamine (DA) is a biogenic monoamine reported to modulate insect hemocytes. Although the immune functions of DA are known in insects, there is a lack of knowledge of DA’s role in the immune system of ticks. The use of Metarhizium anisopliae has been considered for tick control, driving studies on the immune response of these arthropods challenged with fungi. The present study evaluated the effect of DA on the cellular immune response and survival of Rhipicephalus microplus inoculated with M. anisopliae blastospores. Exogenous DA increased both ticks’ survival 72 h after M. anisopliae inoculation and the number of circulating hemocytes compared to the control group, 24 h after the treatment. The phagocytic index of tick hemocytes challenged with M. anisopliae did not change upon injection of exogenous DA. Phenoloxidase activity in the hemolymph of ticks injected with DA and the fungus or exclusively with DA was higher than in untreated ticks or ticks inoculated with the fungus alone, 72 h after treatment. DA was detected in the hemocytes of fungus-treated and untreated ticks. Unveiling the cellular immune response in ticks challenged with entomopathogenic fungi is important to improve strategies for the biological control of these ectoparasites.read more
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Inhibition of Dopamine Activity and Response of Rhipicephalus microplus Challenged with Metarhizium anisopliae
Victória Silvestre Bório,Thaís Almeida Corrêa,Jéssica Fiorotti,Emily Mesquita,Laura Nóbrega Meirelles,Mariana Guedes Camargo,Vânia Rita Elias Pinheiro Bittencourt,Patrícia Silva Gôlo +7 more
TL;DR: In this article , the effect of a dopamine receptor antagonist on the survival, biological parameters, phagocytic index, and dopamine detection in the hemocytes of ticks challenged by Metarhizium anisopliae was analyzed.
References
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Reassessment of the potential economic impact of cattle parasites in Brazil
Laerte Grisi,Romário Cerqueira Leite,João Ricardo Martins,Antonio Thadeu Medeiros de Barros,Renato Andreotti,Paulo Henrique Duarte Cançado,Adalberto A. Pérez de León,Jairo Barros Pereira,Humberto Silva Villela +8 more
TL;DR: Economic losses caused by cattle parasites in Brazil were estimated on an annual basis, considering the total number of animals at risk and the potential detrimental effects of parasitism on cattle productivity, to be at least USD 13.96 billion.